Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with suramin. Determined by electron microscopy at 2.5 Å resolution. Released 19 Aug 2026.
Explore 22TH in 3D Show helices and sheets RCSB PDB PDBe
22TH contains 91 α-helices and 42 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 931-946 | 16 | |
| β-strand | 947 | 1 | 1 |
| β-strand | 953 | 1 | 1 |
| α-helix | 956-963 | 8 | |
| α-helix | 964-969 | 6 | |
| β-strand | 970-972 | 3 | 2 |
| α-helix | 974-986 | 13 | |
| α-helix | 988-996 | 9 | |
| β-strand | 1003-1004 | 2 | 3 |
| α-helix | 1009-1024 | 16 | |
| α-helix | 1029-1040 | 12 | |
| α-helix | 1045-1056 | 12 | |
| β-strand | 1057 | 1 | 4 |
| α-helix | 1058-1060 | 3 | |
| α-helix | 1063-1065 | 3 | |
| α-helix | 1077-1080 | 4 | |
| α-helix | 1090-1092 | 3 | |
| α-helix | 1105-1111 | 7 | |
| α-helix | 1119-1138 | 20 | |
| β-strand | 1143-1145 | 3 | 5 |
| β-strand | 1150-1153 | 4 | 5 |
| α-helix | 1174-1191 | 18 | |
| α-helix | 1198-1208 | 11 | |
| β-strand | 1219-1220 | 2 | 5 |
| α-helix | 1222-1231 | 10 | |
| β-strand | 1262 | 1 | 6 |
| β-strand | 1264 | 1 | 4 |
| α-helix | 1267-1280 | 14 | |
| β-strand | 1283 | 1 | 7 |
| α-helix | 1292-1295 | 4 | |
| α-helix | 1298-1308 | 11 | |
| α-helix | 1316-1327 | 12 | |
| β-strand | 1330 | 1 | 7 |
| α-helix | 1331-1349 | 19 | |
| β-strand | 1357-1362 | 6 | 5 |
| α-helix | 1363 | 1 | |
| β-strand | 1369-1374 | 6 | 5 |
| β-strand | 1382-1387 | 6 | 5 |
| β-strand | 1393-1400 | 8 | 5 |
| α-helix | 1402-1425 | 24 | |
| α-helix | 1429-1434 | 6 | |
| α-helix | 1437-1462 | 26 | |
| α-helix | 1466-1480 | 15 | |
| α-helix | 1488-1501 | 14 | |
| α-helix | 1502-1506 | 5 | |
| α-helix | 1508-1513 | 6 | |
| α-helix | 1516-1530 | 15 | |
| α-helix | 1531-1533 | 3 | |
| β-strand | 1534-1537 | 4 | 3 |
| α-helix | 1539-1546 | 8 | |
| β-strand | 1550 | 1 | 6 |
| α-helix | 1553-1571 | 19 | |
| α-helix | 1573-1580 | 8 | |
| α-helix | 1591 | 1 | |
| β-strand | 1592 | 1 | 8 |
| α-helix | 1593 | 1 | |
| β-strand | 1600 | 1 | 8 |
| α-helix | 1604-1611 | 8 | |
| α-helix | 1613-1615 | 3 | |
| α-helix | 1631-1650 | 20 | |
| α-helix | 1658-1665 | 8 | |
| β-strand | 1753-1755 | 3 | 2 |
| α-helix | 1759-1772 | 14 | |
| α-helix | 1781-1791 | 11 | |
| α-helix | 1792-1794 | 3 | |
| α-helix | 1797-1805 | 9 | |
| α-helix | 1807-1809 | 3 | |
| α-helix | 1836-1845 | 10 | |
| α-helix | 2296-2305 | 10 | |
| α-helix | 2317-2335 | 19 | |
| β-strand | 2339 | 1 | 3 |
| β-strand | 2347-2358 | 12 | 3 |
| α-helix | 2371-2378 | 8 | |
| α-helix | 2383-2396 | 14 | |
| β-strand | 2399-2402 | 4 | 9 |
| α-helix | 2403-2404 | 2 | |
| α-helix | 2405-2417 | 13 | |
| α-helix | 2431-2439 | 9 | |
| α-helix | 2441-2444 | 4 | |
| α-helix | 2449-2453 | 5 | |
| α-helix | 2454-2458 | 5 | |
| β-strand | 2464-2467 | 4 | 9 |
| α-helix | 2477-2502 | 26 | |
| β-strand | 2507-2515 | 9 | 3 |
| β-strand | 2518-2529 | 12 | 3 |
| α-helix | 2531-2558 | 28 | |
| α-helix | 2562-2564 | 3 | |
| β-strand | 2568-2570 | 3 | 3 |
| β-strand | 2574-2576 | 3 | 10 |
| β-strand | 2579-2581 | 3 | 10 |
| β-strand | 2586-2587 | 2 | 10 |
| α-helix | 2590-2593 | 4 | |
| α-helix | 2596-2599 | 4 | |
| α-helix | 2606-2622 | 17 | |
| β-strand | 2623 | 1 | 11 |
| α-helix | 2627-2644 | 18 | |
| α-helix | 2646-2656 | 11 | |
| α-helix | 2661-2663 | 3 | |
| α-helix | 2672-2674 | 3 | |
| α-helix | 2679-2696 | 18 | |
| α-helix | 2702 | 1 | |
| β-strand | 2703 | 1 | 12 |
| α-helix | 2704 | 1 | |
| α-helix | 2754-2763 | 10 | |
| α-helix | 2771-2782 | 12 | |
| α-helix | 2802-2804 | 3 | |
| α-helix | 2807-2815 | 9 | |
| α-helix | 2817-2835 | 19 | |
| β-strand | 2837 | 1 | 13 |
| β-strand | 2860 | 1 | 13 |
| α-helix | 2900-2910 | 11 | |
| α-helix | 2951-2954 | 4 | |
| α-helix | 2994-3002 | 9 | |
| β-strand | 3004-3009 | 6 | 12 |
| β-strand | 3027-3031 | 5 | 12 |
| β-strand | 3037-3042 | 6 | 12 |
| α-helix | 3043-3059 | 17 | |
| α-helix | 3063-3072 | 10 | |
| β-strand | 3078-3081 | 4 | 14 |
| β-strand | 3086-3089 | 4 | 11 |
| α-helix | 3094-3098 | 5 | |
| α-helix | 3105-3113 | 9 | |
| α-helix | 3116-3121 | 6 | |
| α-helix | 3128-3130 | 3 | |
| α-helix | 3131-3141 | 11 | |
| α-helix | 3143-3162 | 20 | |
| α-helix | 3165-3167 | 3 | |
| α-helix | 3168-3184 | 17 | |
| α-helix | 3192-3194 | 3 | |
| β-strand | 3196-3199 | 4 | 11 |
| α-helix | 3206-3207 | 2 | |
| α-helix | 3209-3216 | 8 | |
| β-strand | 3221-3224 | 4 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| RNA-directed RNA polymerase L | A | protein | 3974 | Crimean-Congo hemorrhagic fever virus strain IbAr10200 | Q6TQR6 (AlphaFold model) |
>22TH_1 RNA-directed RNA polymerase L (chains A) MDFLRSLDWTQVIAGQYVSNPRFNISDYFEIVRQPGDGNCFYHSIAELTMPNKTDHSYHY IKRLTESAARKYYQEEPEARLVGLSLEDYLKRMLSDNEWGSTLEASMLAKEMGITIIIWT VAASDEVEAGIKFGDGDVFTAVNLLHSGQTHFDALRILPQFETDTREALSLMDRVIAVDQ LTSSSSDELQDYEDLALALTSAEESNRRSSLDEVTLSKKQAEILRQKASQLSKLVNKSQN IPTRVGRVLDCMFNCKLCVEISADTLILRPESKEKIGEIMSLRQLGHKLLTRDKQIKQEF SRMKLYVTKDLLDHLDVGGLLRAAFPGTGIERHMQLLHSEMILDICTVSLGVMLSTFLYG SNNKNKKKFITNCLLSTALSGKKVYKVLGNLGNELLYKAPRKALATVCSALFGKQINKLQ NCFRTISPVSLLALRNLDFDCLSVQDYNGMIENMSKLDNTDVEFNHREIADLNQLTSRLI TLRKEKDTDLLKQWFPESDLTRRSIRNAANAEEFVISEFFKKKDIMKFISTSGRAMSAGK IGNVLSYAHNLYLSKSSLNMTSEDISQLLIEIKRLYALQEDSEVEPIAIICDGIESNMKQ LFAILPPDCARECEVLFDDIRNSPTHSTAWKHALRLKGTAYEGLFANCYGWQYIPEDIKP SLTMLIQTLFPDKFEDFLDRTQLHPEFRDLTPDFSLTQKVHFKRNQIPSVENVQISIDAT LPESVEAVPVTERKMFPLPETPLSEVHSIERIMENFTRLMHGGRLSTKKRDGDPAEQGNQ QSITEHESSSISAFKDYGERGIVEENHMKFSGEDQLETRQLLLVEVGFQTDIDGKIRTDH KKWKDILKLLELLGIKCSFIACADCSSTPPDRWWITEDRVRVLKNSVSFLFNKLSRNSPT EVTDIVVGAISTQKVRSYLKAGTATKTPVSTKDVLETWEKMKEHILNRPTGLTLPTSLEQ AMRKGLVEGVVISKEGSESCINMLKENLDRITDEFERTKFKHELTQNITTSEKMLLSWLS EDIKSSRCGECLSNIKKAVDETANLSEKIELLAYNLQLTNHCSNCHPNGVNISNTSNVCK RCPKIEVVSHCENKGFEDSNECLTDLDRLVRLTLPGKTEKERRVKRNVEYLIKLMMSMSG IDCIKYPTGQLITHGRVSAKHNDGNLKDRSDDDQRLAEKIDTVRKELSESKLKDYSTYAR GVISNSLKNLSRQGKSKCSVPRSWLEKVLFDLKVPTKDEEVLINIRNSLKARSEFVRNND KLLIRSKEELKKCFDVQSFKLKKNKQPVPFQVDCILFKEVAAECMKRYIGTPYEGIVDTL VSLINVLTRFTWFQEVVLYGKICETFLRCCTEFNRSGVKLVKIRHCNINLSVKLPSNKKE NMLCCLYSGNMELLQGPFYLNRRQAVLGSSYLYIVITLYIQVLQQYRCLEVINSVSEKTL QDIENHSMTLLEDSFREITFALEGRFEESYKIRTSRCRASGNFLNRSSRDHFISVVSGLN LVYGFLIKDNLLANSQQQNKQLQMLRFGMLAGLSRLVCPNELGKKFSTSCRRIEDNIARL YLQTSIYCSVRDVEDNVKHWKQRDLCPEVTIPCFTVYGTFVNSDRQLIFDIYNVHIYNKE MDNFDEGCISVLEETAERHMLWELDLMNSLCSDEKKDTRTARLLLGCPNVRKAANREGKK LLKLNSDTSTDTQSIASEVSDRRSYSSSKSRIRSIFGRYNSQKKPFELRSGLEVFNDPFN DYQQAITDICQFSEYTPNKESILKDCLQIIRKNPSHTMGSFELIQAISEFGMSKFPPENI DKARRDPKNWVSISEVTETTSIVASPRTHMMLKDCFKIILGTENKKIVKMLRGKLKKLGA ISTNIEIGKRDCLDLLSTVDGLTDQQKENIVNGIFEPSKLSFYHWKELVKKNIDEVLLTE DGNLIFCWLKTISSSVKGSLKKRLKFMNIHSPELMPENCLFSSEEFNELIKLKKLLLNEQ QDEQELKQDLLISSWIKCITACKDFASINDKIQKFIYHLSEELYDIRLQHLELSKLKQEH PSVSFTKEEVLIKRLEKNFLKQHNLEIMETVNLVFFAALSAPWCLHYKALESYLVRHPEI LDCGSKEDCKLTLLDLSVSKLLVCLYQKDDEELINSSSLKLGFLVKYVVTLFTSNGEPFS LSLNDGGLDLDLHKTTDEKLLHQTKIVFAKIGLSGNSYDFIWTTQMIANSNFNVCKRLTG RSTGERLPRSVRSKVIYEMVKLVGETGMAILQQLAFAQALNYEHRFYAVLAPKAQLGGAR DLLVQETGTKVMHATTEMFSRNLLKTTSDDGLTNPHLKETILNVGLDCLANMRNLDGKPI SEGSNLVNFYKVICISGDNTKWGPIHCCSFFSGMMQQVLKNVPDWCSFYKLTFIKNLCRQ VEIPAGSIKKILNVLRYRLCSKGGVEQHSEEDLRRLLTDNLDSWDGNDTVKFLVTTYISK GLMALNSYNHMGQGIHHATSSVLTSLAAVLFEELAIFYLKRSLPQTTVHVEHAGSSDDYA KCIVVTGILSKELYSQYDETFWKHACRLKNFTAAVQRCCQMKDSAKTLVSDCFLEFYSEF MMGYRVTPAVIKFMFTGLINSSVTSPQSLMQACQVSSQQAMYNSVPLVTNTAFTLLRQQI FFNHVEDFIRRYGILTLGTLSPFGRLFVPTYSGLVSSAVALEDAEVIARAAQTLQMNSVS IQSSSLTTLDSLGRSRTSSTAEDSSSVSDTTAASHDSGSSSSSFSFELNRPLSETELQFI KALSSLKSTQACEVIQNRITGLYCNSNEGPLDRHNVIYSSRMADSCDWLKDGKRRGNLEL ANRIQSVLCILIAGYYRSFGGEGTEKQVKASLNRDDNKIIEDPMIQLIPEKLRRELERLG VSRMEVDELMPSISPDDTLAQLVAKKLISLNVSTEEYSAEVSRLKQTLTARNVLHGLAGG IKELSLPIYTIFMKSYFFKDNVFLSLTDRWSTKHSTNYRDSCGKQLKGRIITKYTHWLDT FLGCSVSINRHTTVKEPSLFNPNIRCVNLITFEDGLRELSVIQSHLKVFENEFTNLNLQF SDPNRQKLRIVESRPAESELEANRAVIVKTKLFSATEQVRLSNNPAVVMGYLLDESAISE VKPTKVDFSNLLKDRFKIMQFFPSVFTLIKMLTDESSDSEKSGLSPDLQQVARYSNHLTL LSRMIQQAKPTVTVFYMLKGNLMNTEPTVAELVSYGIKEGRFFRLSDTGVDASTYSVKYW KILHCISAIGCLPLSQADKSSLLMSFLNWRVNMDIRTSDCPLSSHEASILSEFDGQVIAN ILASELSSVKRDSEREGLTDLLDYLNSPTELLKKKPYLGTTCKFNTWGDSNRSGKFTYSS RSGESIGIFIAGKLHIHLSSESVALLCETERQVLSWMSKRRTEVITKEQHQLFLSLLPQS HECLQKHKDGSALSVIPDSSNPRLLKFVPLKKGLAVVKIKKQILTVKKQVVFDAESEPRL QWGHGCLSIVYDETDTQTTYHENLLKVKHLVDCSTDRKKLLPQSVFSDSKVVLSRIKFKT ELLLNSLTLLHCFLKHAPSDAIMEVESKSSLLHKYLKSGGVRQRNTEVLFREKLNKVVIK DNLEQGVEEEIEFCNNLTKTVSENPLPLSCWSEVQNYIEDIGFNNVLVNIDRNTVKSELL WKFTLDTNVSTTSTIKDVRTLVSYVSTETIPKFLLAFLLYEEVLMNLINQCKAVKELINS TGLSDLELESLLTLCAFYFQSECSKRDGPRCSFAALLSLIHEDWQRIGKNILVRANNELG DVSLKVNIVLVPLKDMSKPKSERVVMARRSLNHALSLMFLDEMSLPELKSLSVNCKMGNF EGQECFEFTILKDNSARLDYNKLIDHCVDMEKKREAVRAVEDLILMLTGRAVKPSAVTQF VHGDEQCQEQISLDDLMANDTVTDFPDREAEALKTGNLGFNWDSDWSHPQFEKGSSGGSS GSSGGAWSHPQFEK
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
| MN | Manganese (II) ion | Mn | 1 |
| MG | Magnesium ion | Mg | 1 |
| SVR | 8,8'-[carbonylbis[imino-3,1-PHENYLENECARBONYLIMINO(4-methyl-3,1-phenylene)carbo… | C51 H40 N6 O23 S6 | 5 |
Cryo-EM structures of CCHFV polymerase reveal a stepwise initiation stabilization pathway and a dual-site inhibition mechanism. Yang, K., Wu, H., Liu, X. et al. Cell Rep (2026) 45:117945-117945. DOI 10.1016/j.celrep.2026.117945 · PubMed
Other PDB entries of the same protein (UniProt Q6TQR6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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