27PZ: Dynein heavy chain, cytoplasmic

Dictyostelium discoideum cytoplasmic dynein motor domain in the presence of ADP (ADP state 2). Determined by electron microscopy at 3.2 Å resolution. Released 26 Aug 2026.

Method
Electron microscopy
Resolution
3.2 Å
Organism
Dictyostelium discoideum AX2
Chains
1
Atoms
24,643
Mol. weight
386.14 kDa
Ligands
ADP, ATP, MG
Released
26 Aug 2026

Explore 27PZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

27PZ contains 164 α-helices and 81 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 164 helices, 81 β-strands

ElementResiduesLengthSheet
α-helix1402-14065
α-helix1409-14157
α-helix1424-143613
α-helix1443-14453
α-helix1457-14615
α-helix1462-147211
α-helix1478-14858
α-helix1499-15035
α-helix1511-154030
β-strand154211
β-strand1545-154842
β-strand1552-155542
α-helix1558-157518
α-helix1585-162137
α-helix1625-16284
α-helix1630-165122
β-strand165511
α-helix1656-16605
α-helix1665-169329
α-helix1695-16995
α-helix1702-17109
α-helix1715-17173
α-helix1722-17254
β-strand1729-173463
β-strand1740-174673
β-strand1751-175993
α-helix1771-179222
α-helix1800-180910
α-helix1812-183120
α-helix1838-186326
α-helix1869-189426
α-helix1904-19074
β-strand1911-191444
α-helix1921-19233
β-strand1925-192844
β-strand1933-193534
α-helix1951-196515
β-strand1969-197355
α-helix1980-199011
β-strand1995-199735
α-helix2006-201914
β-strand2022-202545
α-helix2028-20303
α-helix2033-205119
β-strand2056-205836
β-strand2064-206636
α-helix2067-20682
β-strand2072-207545
β-strand207715
β-strand207917
α-helix2081-20833
β-strand208517
β-strand2095-209955
α-helix2105-211511
α-helix2121-213515
α-helix2149-216517
α-helix2167-21682
α-helix2173-21764
α-helix2179-220224
α-helix2204-22063
α-helix2209-22113
α-helix2212-22165
α-helix2234-224613
α-helix2253-226816
β-strand2272-227548
α-helix2282-229716
β-strand2300-230349
β-strand230618
α-helix2313-23164
β-strand2319-2320210
β-strand2327-2328210
α-helix2331-23366
α-helix2337-23415
β-strand2349-235249
β-strand2355-235628
β-strand2376-2377211
β-strand2385-2386211
β-strand2391-239229
β-strand2395-239628
α-helix2405-24084
β-strand2412-241548
α-helix2418-24203
α-helix2423-243614
α-helix2441-245616
α-helix2489-250214
α-helix2511-252111
α-helix2530-255425
α-helix2562-258120
α-helix2582-25843
α-helix2587-259913
α-helix2612-26143
β-strand2615-2617312
β-strand2624-2626312
α-helix2627-26293
α-helix2638-26403
α-helix2651-266515
β-strand2671-2673313
α-helix2680-269011
β-strand2694-2699613
α-helix2707-271711
β-strand2718-2722514
β-strand2728-2732514
β-strand2738-2743613
α-helix2750-27512
α-helix2758-276912
β-strand2771-2774414
β-strand2779-2783514
β-strand2786-2792713
α-helix2802-28043
α-helix2805-28084
β-strand2813-2815313
α-helix2818-28203
α-helix2821-283515
α-helix2836-28383
α-helix2840-28423
α-helix2846-286318
α-helix2876-289116
α-helix2898-290912
α-helix2910-29145
α-helix2920-29234
α-helix2926-293712
β-strand2953115
β-strand2961115
α-helix2965-298218
α-helix2987-29904
α-helix2992-300514
β-strand3012-3015416
α-helix3024-30329
β-strand3036-3039416
α-helix3052-30587
β-strand3061117
β-strand3063117
β-strand3069-3073516
α-helix3083-30875
α-helix3088-30914
α-helix3105-31128
α-helix3116-31183
α-helix3129-31379
β-strand3141-3147716
α-helix3161-31677
β-strand3169-3172416
α-helix3175-31773
α-helix3178-318811
α-helix3203-321210
α-helix3223-324927
α-helix3257-330953
α-helix3553-358634
α-helix3588-360114
α-helix3602-36043
α-helix3607-362418
α-helix3634-36374
α-helix3641-36499
α-helix3656-366611
β-strand3671-3675518
α-helix3680-36889
α-helix3690-36923
β-strand3695-3698418
α-helix3704-371411
β-strand3718-3721418
α-helix3723-37253
α-helix3728-37303
α-helix3731-37344
β-strand3739-3741319
β-strand3744-3747419
β-strand3754-3755219
β-strand3762-3766518
α-helix3775-37784
β-strand3781-3785518
α-helix3790-380516
α-helix3807-38148
α-helix3817-384024
α-helix3844-38463
α-helix3850-390253
α-helix3903-39053
α-helix3913-392412
α-helix3928-39303
α-helix3936-395520
α-helix3961-39644
α-helix3966-397510
α-helix3982-39843
α-helix3985-39928
α-helix3998-40003
α-helix4006-40083
α-helix4016-402611
α-helix4028-40303
α-helix4033-40397
α-helix4057-40593
α-helix4060-406910
α-helix4075-408814
α-helix4091-40933
α-helix4094-410512
α-helix4118-41203
α-helix4121-41255
β-strand4132-4136520
α-helix4144-41529
β-strand4157-4161520
β-strand4162121
β-strand4164121
α-helix4165-418117
β-strand4184-4188520
α-helix4190-41923
α-helix4194-420411
β-strand4215-4220620
α-helix4227-42326
β-strand4234-4238520
α-helix4240-42423
α-helix4244-425310
α-helix4257-42604
α-helix4265-428117
α-helix4284-42874
α-helix4300-431819
α-helix4331-43366
α-helix4337-43437
α-helix4350-436314
α-helix4366-43694
β-strand4374-4376322
α-helix4377-43793
β-strand4381-4382222
α-helix4389-43979
α-helix4405-44084
α-helix4414-444229
α-helix4459-447618
α-helix4489-44924
α-helix4494-452532
α-helix4534-45374
α-helix4540-45434
α-helix4546-45472
α-helix4561-458020
α-helix45881
β-strand4589-4590223
α-helix4591-45933
α-helix4597-461115
β-strand4620-4626723
β-strand4636-4640523
β-strand4643-4645324
β-strand4648-4650325
β-strand4653-4655325
β-strand4661-4663324
β-strand4667-4672623
α-helix4677-46848
β-strand4686-4691624
β-strand4699-4705724
β-strand4707125
α-helix4713-47197
β-strand4722-4724324

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Dynein heavy chain, cytoplasmicAprotein3367Dictyostelium discoideum AX2P34036
Sequence of entity 1 (A), FASTA
>27PZ_1 Dynein heavy chain, cytoplasmic (chains A)
MTRHHHHHHGGGDYKDDDDKGGGKVPVEEEIQDLKAVWVELSNTWQEIDSLKETAWSAII
PRKVRKSLEDTLQKLKNLPNRIRQYSAFDHAQNLIKIYLKGNAIITDLHSEAIKDRHWKI
LKKRLNTNWIITELTLGSIWDSDLARNENIYREVITAAQGEIALEEFLKGVREFWTTLEL
DLVNYQRKCKLVRGWDDLFNKLAEHLNSISAMKMSPYYKVFEEEANHWDDRLNKVRSLLD
VWIDVQRRWVYLEGIFSGSGDINQLLPAESTRFKSINSEFIAILKKVSGAPLILEVLAIE
RIQQTMERLSDLLGKVQKALGEYLERQRSAFARFYFVGDEDLLEIIGNSKDIIKIQKHFR
KMFAGLANLTLDDEKTTIIGMSSAEGETVTFKKPISIANGPKIHEWLTMVESEMKSTLAT
LLSESLQHFNQVDVNDHSKYSEWVDNYPTQLVLLTSQIVWSTQVDQALGGGTLQQSKIQE
QLQSIEQTTQMILNNLADSVLQDLSAQKRKKFEHLITELVHQRDVVRQLQKCKNLTGNKD
FDWLYHMRYYYDATQENVLHKLVIHMANATFYYGFEYLGIGERLVQTPLTDRCYLTLTQA
LESRMGGNPFGPAGTGKTETVKALGSQLGRFVLVFCCDEGFDLQAMSRIFVGLCQCGAWG
CFDEFNRLEERILSAVSQQIQTIQVALKENSKEVELLGGKNISLHQDMGIFVTMNPGYAG
RSNLPDNLKKLFRSMAMIKPDREMIAQVMLYSQGFKTAEVLAGKIVPLFKLCQEQLSAQS
HYDFGLRALKSVLVSAGGIKRKCQPPQLPPITDAESKTKADQIYCQYEIGVLLNSINDTM
IPKLVADDIPLIQSLLLDVFPGSQLQPIQMDQLRKKIQEIAKQRHLVTKQEWVEKILQLH
QILNINHGVMMVGPSGGGKTTSWEVYLEAIEQVDNIKSEAHVMDPKAITKDQLFGSLDLT
TREWTDGLFTATLRRIIDNVRGESTKRHWIIFDGDVDPEWVENLNSLLDDNKLLTLPNGE
RLALPNNVRVMFEVQDLKYATLATISRCGMVWFSEEILTTQMIFQNYLDTLSNEPFDPQE
KEQQKRNENAQLQQQQQTTITSPILTSPPTTSSSSRSTTSTTSMIPAGLKVQKECAAIIS
QYFEPGGLVHKVLEDAGQRPHIMDFTRLRVLNSFFSLMNRSIVNVIEYNQLHSDFPMSPE
NQSNYITNRLLYSLMWGLGGSMGLVERENFSKFIQTIAITPVPANTIPLLDYSVSIDDAN
WSLWKNKVPSVEVETHKVASPDVVIPTVDTTRHVDVLHAWLSEHRPLILCGPPGSGKTMT
LTSTLRAFPDFEVVSLNFSSATTPELLLKTFDHHCEYKRTPSGETVLRPTQLGKWLVVFC
DEINLPSTDKYGTQRVITFIRQMVEKGGFWRTSDHTWIKLDKIQFVGACNPPTDAGRVQL
THRFLRHAPILLVDFPSTSSLTQIYGTFNRALMKLLPNLRSFADNLTDAMVEFYSESQKR
FTPDIQAHYIYSPRELSRWDRALLEAIQTMDGCTLEGLVRLWAHEALRLFQDRLVETEEK
EWTDKKIDEVALKHFPSVNLDALKRPILYSNWLTKDYQPVNRSDLREYVKARLKVFYEEE
LDVPLVLFNEVLDHILRIDRVFRQPQGHALLIGVSGGGKSVLSRFVAWMNGLSIYTIKVN
NNYKSSDFDDDLRMLLKRAGCKEEKICFIFDESNVLESSFLERMNTLLAGGEVPGLFEGE
EFTALMHACKETAQRNGLILDSEEELYKYFTSQVRRNLHVVFTMNPASPDFHNRSATSPA
LFNRCVLDWFGEWSPEALFQVGSEFTRNLDLENPQYIAPPVFIQEAEIMGNNLMAIPPSH
RDAVVSSLVYIHQTIGEANIRLLKRQGRQNYVTPRHYLDFINQVVLLINEKRDQLEEEQL
HLNIGLKKLRDTEAQVKDLQVSLAQKNRELDVKNEQANQKLKQMVQDQQAAEIKQKDARE
LQVQLDVRNKEIAVQKVKAYADLEKAEPAIIEAQEAVSTIKKKHLDEIKSLPKPPTPVKL
AMEAVCLMLGGKKLEWADIRKKIMEPNFITSIINYDTKKMMTPKIREAITKGYLEDPGFD
YETVNRASKACGPLVKWATAQTYYSEILDRIKPLREEVEQLENAANELKLKQDEIVATIT
ALEKSIATYKEEYATLIRETEQIKTESSKVKNKVDRSIALLDNLNSERGRWEQQSENFNT
QMSTVVGDVVLASAFLAYIGFFDQNFRTDLMRKWMIRLDSVGIKFKSDLSVPSFLSKPEE
RLNWHANSLPSDELCIENAIMLKRFNRYPLVIDPSGQAMEFLMNQYADKKITKTSFLDSS
FMKNLESALRFGCPLLVQDVENIDPVLNPVLNKEIRKKGGRILIRLGDQDVDFSPSFMIF
LFTRDPTAHFTPDLCSRVTFVNFTVTPSSLQSQCLHEALKTERPDTHKKRSDLLKIQGEF
QVKLRILEKSLLNALSQASGNILDDDSVISTLETLKKETTEIALKVEETETVMQEISEVS
ALYNPMALSCSRVYFAMEELSQFHLYQFSLRAFLDIFYNLLNNNPNLVDKKDPNERLVYL
SKDIFSMTFNRVTRTLLNDDKLTFALQLTIISVKGTSNEIEESEWDFLLKGGDNLTSIKE
TIPQLDSLLSTTQQKWLICLRQQVPSFSKLVDHIQQNSSDWKQFFGKDQVGEPIIPESWI
VAQAQLSNQQSTIVSNFRKILLMKAFHSDRVLQYSHSFVCSVFGEDFLNTQELDMANIVE
KEVKSSSPLLLCSVPGYDASSKVDDLALQLHKQYKSFAIGSPEGFELAEKSIYAAAKSGT
WVLLKNIHLAPQWLVQLEKKLHSLSPHPSFRLFMTSEIHPALPANLLRMSNVFSYENPPG
VKANLLHTFIGIPATRMDKQPAERSRIYFLLAWFHAIIQERLRYIPLGWTKFFEFNDADL
RGALDSIDYWVDLYSKGRSNIDPDKIPWIAVRTILGSTIYGGRIDNEFDMRLLYSFLEQL
FTPSAFNPDFPLVPSIGLSVPEGTTRAHFMKWIEALPEISTPIWLGLPENAESLLLSNKA
RKMINDLQKMQSSEEDGEDDQVSGSSKKESSSSSSEDKGKAKLRATITEWTKLLPKPLKQ
LKRTTQNIKDPLFRCFEREISTGGKLVKKITNDLANLLELISGNIKSTNYLRSLTTSISK
GIVPKEWKWYSVPETISLSVWISDFSKRMQQLSEISESSDYSSIQVWLGGLLNPEAYITA
TRQSASQLNGWSLENLRLHASSLGKISSEGGASFNVKGMALEGAVWNNDQLTPTDILSTP
ISIATLTWKDKDDPIFNNSSSKLSVPVYLNETRSELLFSIDLPYDQSTSKQNWYQRSVSI
SSWKSDI

Ligands and cofactors

IDNameFormulaCopies
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P23
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P31
MGMagnesium ionMg1

Primary citation

ADP-Bound States of Cytoplasmic Dynein: Cryo-electron Microscopy Reveals a Two-Step Post-Power-Stroke Transition and Roles of Regulatory ATPase Sites. Imai, H., Kanazawa, R., Maeshima, T. et al. J Mol Biol (2026) 438:169977-169977. DOI 10.1016/j.jmb.2026.169977 · PubMed

Other PDB entries of the same protein (UniProt P34036), best resolution first:

Browse structure collections

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