28JC: RNA polymerase II

RNA polymerase II bound to RPAP2 and Gdown1. Determined by electron microscopy at 2.94 Å resolution. Released 19 Aug 2026.

Method: Electron microscopy
Resolution: 2.94 Å
Organism: Homo sapiens
Chains: 14
Atoms: 29,492
Mol. weight: 629.19 kDa
Ligands: ZN
Released: 19 Aug 2026

Explore 28JC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

28JC contains 166 α-helices and 202 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 53 helices, 57 β-strands

Element	Residues	Length	Sheet
β-strand	365-366	2	22
β-strand	367-369	3	23
β-strand	377-380	4	23
α-helix	382-387	6
β-strand	389-393	5	24
α-helix	399-408	10
β-strand	416-420	5	24
β-strand	426-428	3	24
α-helix	435-438	4
β-strand	445-449	5	24
α-helix	450	1
β-strand	455-458	4	23
β-strand	470-476	7	23
β-strand	482-484	3	23
β-strand	500-501	2	22
β-strand	504	1	23
α-helix	509-518	10
α-helix	542-548	7
β-strand	554-555	2	25
α-helix	557-565	9
α-helix	573-574	2
β-strand	575	1	10
α-helix	576-577	2
β-strand	579	1	8
β-strand	585	1	8
β-strand	586-587	2	25
α-helix	588-595	8
β-strand	602-605	4	26
α-helix	611-614	4
β-strand	627-631	5	26
β-strand	634-637	4	26
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
α-helix	689-692	4
α-helix	693-695	3
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	27
β-strand	793	1	28
β-strand	796	1	28
α-helix	817-820	4
β-strand	822-823	2	27
α-helix	833-867	35
β-strand	872-873	2	29
β-strand	879-880	2	29
β-strand	886-888	3	29
α-helix	891-893	3
β-strand	896	1	30
β-strand	902-905	4	31
α-helix	913-919	7
α-helix	927-933	7
β-strand	934	1	32
α-helix	936-943	8
α-helix	946-969	24
β-strand	976-979	4	31
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	32
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1079	18
β-strand	1080	1	30
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1121-1128	8
β-strand	1139	1	33
β-strand	1142	1	34
β-strand	1143	1	35
α-helix	1145-1148	4
α-helix	1151-1161	11
β-strand	1164-1165	2	36
α-helix	1166-1169	4
β-strand	1170-1176	7	15
β-strand	1177	1	37
α-helix	1191-1196	6
β-strand	1207	1	38
β-strand	1210	1	37
β-strand	1214-1216	3	15
α-helix	1218-1224	7
α-helix	1228-1238	11
β-strand	1243-1247	5	15
α-helix	1248-1249	2
β-strand	1255-1261	7	15
β-strand	1262	1	38
α-helix	1281-1295	15
β-strand	1297-1299	3	36
β-strand	1304-1307	4	33
β-strand	1310	1	34
β-strand	1319-1322	4	39
β-strand	1328-1331	4	39
β-strand	1335	1	34
β-strand	1338-1340	3	33
α-helix	1343-1346	4
β-strand	1352	1	35
β-strand	1359	1	33
α-helix	1362-1368	7
α-helix	1371-1387	17
α-helix	1395-1406	12
β-strand	1408	1	2
α-helix	1411-1412	2
β-strand	1471-1475	5	5
α-helix	1477-1480	4
β-strand	1484	1	4

Chain B: 46 helices, 65 β-strands

Element	Residues	Length	Sheet
α-helix	19-36	18
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-60	6
α-helix	63-64	2
β-strand	65-67	3	21
β-strand	83-88	6	21
β-strand	92-93	2	21
β-strand	97-99	3	40
β-strand	105-107	3	40
α-helix	110-116	7
β-strand	121-133	13	21
β-strand	141-153	13	21
α-helix	168-173	6
β-strand	185-187	3	41
β-strand	190-193	4	41
β-strand	196-200	5	42
α-helix	201	1
β-strand	205-209	5	43
β-strand	215-223	9	43
β-strand	233-240	8	43
β-strand	256-258	3	43
β-strand	263	1	44
β-strand	267-268	2	43
α-helix	269-276	8
α-helix	281-288	8
α-helix	297-301	5
α-helix	302-307	6
α-helix	314-322	9
β-strand	325	1	44
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-377	20
α-helix	381-384	4
β-strand	391-394	4	42
α-helix	396-423	28
α-helix	431-434	4
α-helix	437-450	14
β-strand	453	1	45
β-strand	463	1	45
β-strand	468-469	2	41
α-helix	470	1
α-helix	475-482	8
β-strand	484-486	3	42
α-helix	492-495	4
α-helix	503-505	3
β-strand	509	1	46
β-strand	523-525	3	42
β-strand	526	1	46
β-strand	531-532	2	47
α-helix	539-548	10
β-strand	551	1	48
α-helix	553-555	3
α-helix	558-561	4
β-strand	565-569	5	48
β-strand	572-577	6	48
α-helix	580-592	13
β-strand	604-606	3	48
β-strand	611-613	3	48
β-strand	621-627	7	47
β-strand	628	1	49
β-strand	633	1	49
α-helix	637-644	8
α-helix	646-648	3
α-helix	653-658	6
β-strand	662-666	5	47
α-helix	669-672	4
β-strand	675-676	2	47
α-helix	679-683	5
β-strand	695-696	2	47
α-helix	700-703	4
α-helix	719-731	13
β-strand	732	1	50
β-strand	748-751	4	19
β-strand	759-760	2	51
β-strand	776-782	7	52
β-strand	793-797	5	52
α-helix	798-802	5
β-strand	808-811	4	19
β-strand	814-817	4	19
β-strand	826-829	4	53
β-strand	839	1	53
β-strand	848	1	54
β-strand	853	1	55
β-strand	854	1	54
α-helix	855	1
β-strand	859-860	2	19
β-strand	867	1	55
β-strand	869-872	4	53
β-strand	890-891	2	53
β-strand	894	1	55
β-strand	902-911	10	19
β-strand	917-927	11	19
β-strand	934-936	3	52
β-strand	943-949	7	52
β-strand	965-967	3	52
α-helix	969-971	3
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	51
α-helix	1008-1015	8
α-helix	1016-1018	3
β-strand	1025-1026	2	52
α-helix	1028	1
β-strand	1029	1	56
α-helix	1030	1
β-strand	1036	1	56
α-helix	1037	1
β-strand	1041-1050	10	52
β-strand	1051	1	50
α-helix	1056-1060	5

Chain C: 12 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	57
β-strand	18-24	7	57
α-helix	28-39	12
β-strand	44-55	12	20
α-helix	61-70	10
β-strand	72	1	20
β-strand	73	1	58
α-helix	78-81	4
β-strand	99-106	8	20
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	20
β-strand	129	1	58
α-helix	130-132	3
α-helix	147-148	2
β-strand	149-153	5	59
β-strand	158-168	11	20
α-helix	174-176	3
β-strand	179-185	7	57
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	57
α-helix	241-270	30

Chain D: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	25-28	4
α-helix	34-50	17
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	118-120	3
α-helix	124-137	14

Chain E: 11 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	4-23	20
β-strand	26-27	2	1
α-helix	30-33	4
α-helix	37-43	7
α-helix	56-58	3
β-strand	60-64	5	1
β-strand	71-75	5	1
α-helix	84-97	14
β-strand	101-105	5	1
α-helix	112-120	9
β-strand	126-130	5	1
α-helix	132-135	4
β-strand	147-150	4	2
α-helix	151-152	2
α-helix	153-163	11
α-helix	171	1
β-strand	172-173	2	2
α-helix	178-183	6
β-strand	190-196	7	2
β-strand	202-209	8	2

Chain F: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	3
α-helix	59-74	16
β-strand	79	1	4
α-helix	89-99	11
β-strand	104-109	6	5
β-strand	115-118	4	5
β-strand	124	1	3

Chain G: 3 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	5
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	5
β-strand	43-53	11	5
β-strand	58-59	2	5
α-helix	60	1
β-strand	66-77	12	5
β-strand	84-92	9	6
β-strand	97-100	4	6
β-strand	106-107	2	6
β-strand	117-119	3	7
β-strand	128-130	3	7
β-strand	136-137	2	7
β-strand	142-146	5	6
β-strand	150-153	4	6
β-strand	156-160	5	6

Chain H: 3 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	8
β-strand	25-31	7	8
β-strand	38-44	7	8
β-strand	55-61	7	8
β-strand	65	1	9
α-helix	69-71	3
β-strand	74	1	10
β-strand	83	1	9
α-helix	84-87	4
β-strand	90-98	9	8
β-strand	101	1	11
β-strand	111	1	12
β-strand	112	1	11
β-strand	114-118	5	8
β-strand	121-125	5	8
β-strand	128	1	12
α-helix	129-131	3
β-strand	140-147	8	8

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Homo sapiens	O15514 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Homo sapiens	P62487 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Homo sapiens	P36954
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Homo sapiens	P52435
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase II subunit GRINL1A	M	protein	368	Homo sapiens	P0CAP2
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Homo sapiens	P24928
DNA-directed RNA polymerase II subunit RPB2	B	protein	1174	Homo sapiens	P30876

2 more molecules are not listed.

Sequence of entity 1 (D), FASTA

>28JC_1 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 2 (E), FASTA

>28JC_2 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 3 (F), FASTA

>28JC_3 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 4 (G), FASTA

>28JC_4 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 5 (H), FASTA

>28JC_5 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 6 (I), FASTA

>28JC_6 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 7 (J), FASTA

>28JC_7 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 8 (K), FASTA

>28JC_8 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 9 (L), FASTA

>28JC_9 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 10 (M), FASTA

>28JC_10 DNA-directed RNA polymerase II subunit GRINL1A (chains M)
MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKA
AIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDN
IKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEASEHHPRHRVSSQ
AEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVLEMRAK
NPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMP
TQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDED
DDWSSDEF

Sequence of entity 11 (A), FASTA

>28JC_11 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 12 (B), FASTA

>28JC_12 DNA-directed RNA polymerase II subunit RPB2 (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6

Primary citation

Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1. Schmitzova, J., Zhan, Y., Rengachari, S. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-76334-5 · PubMed

Other PDB entries of the same protein (UniProt O15514 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9EHZ 2.6 Å, Cryo-EM structure of Human RNA polymerase II Elongation Complex in an Intermediate…
2C35 2.7 Å, Subunits Rpb4 and Rpb7 of human RNA polymerase II
8XSO 2.7 Å, RNA polymerase II elongation complex transcribing genomic DNA extracted from human nuclei
9T5H 2.7 Å, RNA polymerase II bound to Gdown1 and RPAP2
8XRM 3.13 Å, RNA polymerase II elongation complex with DSIF, SPT6, and ELOF1 transcribing genomic DNA…
9EI1 3.2 Å, Cryo-EM structure of Human RNA polymerase II Elongation Complex bound to the RECQL5…
9EI3 3.2 Å, Cryo-EM structure of Human RNA polymerase II Elongation Complex bound to the RECQL5…
8XRJ 3.6 Å, RNA polymerase II elongation complex with upstream nucleosome extracted from human nuclei
9EI4 3.7 Å, Cryo-EM structure of Human RNA polymerase II Elongation Complex bound to the RECQL5…
5IYB 3.9 Å, Human core-PIC in the open state
5IYC 3.9 Å, Human core-PIC in the initial transcribing state
5IYD 3.9 Å, Human core-PIC in the initial transcribing state (no IIS)

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