2A93: C-myc-max heterodimeric leucine zipper

NMR solution structure of the C-myc-max heterodimeric leucine zipper, 40 structures. Determined by solution NMR. Released 27 Jan 1999.

Method: Solution NMR
Chains: 2
Atoms: 533
Mol. weight: 7.62 kDa
Released: 27 Jan 1999

Explore 2A93 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2A93 contains 2 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	6-32	27

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	6-31	26

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-myc-max heterodimeric leucine zipper	A	protein	34		P01106 (AlphaFold model)
C-myc-max heterodimeric leucine zipper	B	protein	34		P28574 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2A93_1 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER (chains A)
XCGGVQAEEQKLISEEDLLRKRREQLKHKLEQLX

Sequence of entity 2 (B), FASTA

>2A93_2 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER (chains B)
XCGGMRRKNDTHQQDIDDLKRQNALLEQQVRALX

Primary citation

Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. Lavigne, P., Crump, M.P., Gagne, S.M. et al. J Mol Biol (1998) 281:165-181. DOI 10.1006/jmbi.1998.1914 · PubMed

Other PDB entries of the same protein (UniProt P01106 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9QNH 1.3 Å, Myc pS294 phosphopeptide binding to 14-3-3sigma
6G6K 1.35 Å, The crystal structures of Human MYC:MAX bHLHZip complex
1NKP 1.8 Å, Crystal structure of Myc-Max recognizing DNA
8Q1N 1.84 Å, Cyclic peptide binder of the WBM-site of WDR5
4Y7R 1.9 Å, Crystal structure of WDR5 in complex with MYC MbIIIb peptide
8J2Q 1.92 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
5I4Z 1.95 Å, Structure of apo OmoMYC
8X8V 2.0 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
8X8S 2.04 Å, Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment
1EE4 2.1 Å, Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls…
6G6L 2.2 Å, The crystal structures of Human MYC:MAX bHLHZip complex
6G6J 2.25 Å, The crystal structures of Human MYC:MAX bHLHZip complex

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