Crystal structure of cocaine catalytic antibody 7A1 Fab' in complex with heptaethylene glycol. Determined by X-ray diffraction at 1.7 Å resolution. Released 14 Feb 2006.
Explore 2AJS in 3D Show helices and sheets RCSB PDB PDBe
2AJS contains 17 α-helices and 47 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-7 | 5 | 8 |
| β-strand | 11-12 | 2 | 9 |
| β-strand | 18-25 | 8 | 8 |
| β-strand | 34-39 | 7 | 10 |
| β-strand | 45-52 | 8 | 10 |
| β-strand | 56-59 | 4 | 10 |
| α-helix | 61-63 | 3 | |
| β-strand | 67-72 | 6 | 8 |
| α-helix | 73-75 | 3 | |
| β-strand | 77-82 | 6 | 8 |
| α-helix | 84-86 | 3 | |
| β-strand | 88-95 | 8 | 10 |
| β-strand | 103 | 1 | 10 |
| β-strand | 107-109 | 3 | 10 |
| β-strand | 110-111 | 2 | 9 |
| α-helix | 115-116 | 2 | |
| β-strand | 117 | 1 | 11 |
| α-helix | 118-119 | 2 | |
| β-strand | 120-124 | 5 | 12 |
| β-strand | 137-147 | 11 | 12 |
| β-strand | 148 | 1 | 11 |
| β-strand | 153-157 | 4 | 13 |
| α-helix | 162-164 | 3 | |
| β-strand | 166 | 1 | 13 |
| β-strand | 171-173 | 3 | 12 |
| α-helix | 174-176 | 3 | |
| β-strand | 177-179 | 3 | 12 |
| β-strand | 184-194 | 11 | 12 |
| β-strand | 207-212 | 6 | 13 |
| α-helix | 213-215 | 3 | |
| β-strand | 217-222 | 6 | 13 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-6 | 3 | 1 |
| α-helix | 7-9 | 3 | |
| β-strand | 13-14 | 2 | 2 |
| β-strand | 19-25 | 7 | 1 |
| β-strand | 27C | 1 | 3 |
| β-strand | 31 | 1 | 3 |
| β-strand | 33-38 | 6 | 4 |
| β-strand | 45-49 | 5 | 4 |
| β-strand | 53-54 | 2 | 4 |
| α-helix | 55 | 1 | |
| β-strand | 62-66 | 5 | 1 |
| β-strand | 70-75 | 6 | 1 |
| α-helix | 80-82 | 3 | |
| β-strand | 84-90 | 7 | 4 |
| α-helix | 97 | 1 | |
| β-strand | 98 | 1 | 4 |
| α-helix | 99 | 1 | |
| β-strand | 102-104 | 3 | 4 |
| β-strand | 106-107 | 2 | 2 |
| β-strand | 111 | 1 | 5 |
| β-strand | 114-118 | 5 | 6 |
| α-helix | 119-121 | 3 | |
| α-helix | 122-127 | 6 | |
| β-strand | 129-139 | 11 | 6 |
| β-strand | 140 | 1 | 5 |
| β-strand | 145-150 | 6 | 7 |
| β-strand | 153-155 | 3 | 7 |
| β-strand | 159-163 | 5 | 6 |
| α-helix | 164-167 | 4 | |
| β-strand | 173-182 | 10 | 6 |
| α-helix | 183-187 | 5 | |
| β-strand | 191-197 | 7 | 7 |
| β-strand | 205-210 | 6 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Antibody 7A1 FAB' | L | protein | 216 | Mus musculus | P01837 (AlphaFold model) |
| Antibody 7A1 FAB' | H | protein | 219 | Mus musculus | P01869 (AlphaFold model) |
>2AJS_1 Antibody 7A1 FAB' (chains L) DIVITQDELSNPVTSGESVSISCRSSRSLLYKDGRTYLNWFLQRPGQSPQLLIYLMSTRA SGVSDRFSGSGSGTDFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTV SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM SSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR
>2AJS_2 Antibody 7A1 FAB' (chains H) EVKLSESGPGLVKPSQSLSLTCTVTGYSITTNYAWTWIRQFPGNKLEWMGYIRSSVITRY NPSLKSRISITQDTSKNQFFLQLNSVTTEDTATYYCARYDYYGNTGDYWGQGTSVTVSSA KTTPPSVYPLAPGTAALKSSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDL YTLTSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPR
| ID | Name | Formula | Copies |
|---|---|---|---|
| P33 | 3,6,9,12,15,18-hexaoxaicosane-1,20-diol | C14 H30 O8 | 1 |
Water and common crystallization additives (SO4, GOL) are not listed.
Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Zhu, X., Dickerson, T.J., Rogers, C.J. et al. Structure (2006) 14:205-216. DOI 10.1016/j.str.2005.10.014 · PubMed
Other PDB entries of the same protein (UniProt P01837 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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