2BCX: Calmodulin

Crystal structure of calmodulin in complex with a ryanodine receptor peptide. Determined by X-ray diffraction at 2.0 Å resolution. Released 31 Oct 2006.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Gallus gallus
Chains: 2
Atoms: 1,431
Mol. weight: 20.51 kDa
Ligands: CA
Released: 31 Oct 2006

Explore 2BCX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2BCX contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-17	12
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	1
α-helix	65-76	12
α-helix	84-92	9
β-strand	99-100	2	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	2
α-helix	138-144	7

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3617-3638	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Gallus gallus	P62149 (AlphaFold model)
Ryanodine receptor 1	B	protein	30		P11716

Sequence of entity 1 (A), FASTA

>2BCX_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>2BCX_2 Ryanodine receptor 1 (chains B)
KSKKAVWHKLLSKQRRRAVVACFRMTPLYN

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode. Maximciuc, A.A., Putkey, J.A., Shamoo, Y. et al. Structure (2006) 14:1547-1556. DOI 10.1016/j.str.2006.08.011 · PubMed

Other PDB entries of the same protein (UniProt P62149 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2O5G 1.08 Å, Calmodulin-smooth muscle light chain kinase peptide complex
3GOF 1.45 Å, Calmodulin bound to peptide from macrophage nitric oxide synthase
3GP2 1.46 Å, Calmodulin bound to peptide from calmodulin kinase II (CaMKII)
2O60 1.55 Å, Calmodulin bound to peptide from neuronal nitric oxide synthase
1AHR 1.8 Å, Calmodulin mutant with a two residue deletion in the central helix
1UP5 1.9 Å, Chicken Calmodulin
2VB6 2.3 Å, Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2)
5HIT 2.85 Å, Crystal Structure Analysis of Ca2+-calmodulin and a C-terminal EAG1 channel fragment
2BKI 2.9 Å, Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure
6BNV 4.6 Å, CryoEM structure of MyosinVI-actin complex in the rigor (nucleotide-free) state,…
2KZ2 Calmodulin, C-terminal domain, F92E mutant
2M3S Calmodulin, i85l, f92e, h107i, l112r, a128t, m144r mutant

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