2BNU: T-cell receptor alpha chain C region

Structural and kinetic basis for heightened immunogenicity of T cell vaccines. Determined by X-ray diffraction at 1.4 Å resolution. Released 24 May 2005.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 3,705
Mol. weight: 49.22 kDa
Released: 24 May 2005

Explore 2BNU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2BNU contains 11 α-helices and 43 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	1
β-strand	10-14	5	2
β-strand	19-25	7	1
β-strand	30-38	9	2
β-strand	44-51	8	2
β-strand	56-59	4	1
β-strand	62-67	6	1
β-strand	72-77	6	1
α-helix	82-84	3
β-strand	86-94	9	2
β-strand	103-104	2	2
β-strand	108-113	6	2
α-helix	114-115	2
β-strand	122-126	5	3
β-strand	135-140	6	3
β-strand	157-158	2	3
α-helix	159-161	3
β-strand	162-166	5	3
α-helix	167-169	3
β-strand	171-180	10	3
α-helix	187-191	5
β-strand	201	1	3

Chain B: 6 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	4
β-strand	9-13	5	5
β-strand	18-20	3	6
β-strand	21-24	4	4
β-strand	30-37	8	5
β-strand	41-50	10	5
β-strand	53-56	4	5
β-strand	64-65	2	6
β-strand	72	1	4
β-strand	75-77	3	6
α-helix	82-84	3
β-strand	86-93	8	5
β-strand	102-103	2	5
β-strand	107-112	6	5
α-helix	115-117	3
β-strand	119	1	7
α-helix	120-121	2
β-strand	122-126	5	8
α-helix	127-129	3
α-helix	130-136	7
β-strand	138-148	11	8
β-strand	149	1	7
β-strand	153-159	7	9
β-strand	162-164	3	9
β-strand	168-170	3	8
β-strand	175-176	2	8
β-strand	186-195	10	8
α-helix	196-199	4
β-strand	205-212	8	9
β-strand	215	1	10
β-strand	229	1	10
β-strand	231-238	8	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T-cell receptor alpha chain C region	A	protein	203	HOMO SAPIENS	A0A0B4J279 (AlphaFold model), P01848 (AlphaFold model)
T-cell receptor beta chain C region	B	protein	241	HOMO SAPIENS	A0A0K0K1A5 (AlphaFold model), P01850 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2BNU_1 T-CELL RECEPTOR ALPHA CHAIN C REGION (chains A)
QEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGR
LNASLDKSSGRSTLYIAASQPGDSATYLCAVRPTSGGSYIPTFGRGTSLIVHPYIQNPDP
AVYQLRRSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSN
KSDFACANAFNNSIIPEDTFFPS

Sequence of entity 2 (B), FASTA

>2BNU_2 T-CELL RECEPTOR BETA CHAIN C REGION (chains B)
GVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEVPN
GYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPP
EVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPAL
NDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA
D

Primary citation

Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines. Chen, J.-L., Stewart-Jones, G., Bossi, G. et al. J Exp Med (2005) 201:1243. DOI 10.1084/JEM.20042323 · PubMed

Other PDB entries of the same protein (UniProt A0A0B4J279 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4WW1 1.38 Å, Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8 and Beta Chain-TRBV7-8
2BNQ 1.7 Å, Structural and kinetic basis for heightened immunogenicity of T cell vaccines
2P5E 1.89 Å, Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native…
2BNR 1.9 Å, Structural and kinetic basis for heightened immunogenicity of T cell vaccines
5EU6 2.02 Å, HLA Class I antigen
2F53 2.1 Å, Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically…
2P5W 2.2 Å, Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native…
2PYE 2.3 Å, Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative…
5BS0 2.4 Å, MAGE-A3 Reactive TCR in complex with Titin Epitope in HLA-A1
4WW2 2.48 Å, Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8,…
6Q3S 2.5 Å, Engineered Human HLA_A2 MHC Class I molecule in complex with TCR and SV9 peptide
5BRZ 2.62 Å, MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1

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