Crystal structure of socs-2 in complex with elongin-B and elongin-C at 1.9A resolution. Determined by X-ray diffraction at 1.9 Å resolution. Released 22 Feb 2006.
Explore 2C9W in 3D Show helices and sheets RCSB PDB PDBe
2C9W contains 22 α-helices and 23 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 33-45 | 13 | |
| β-strand | 49 | 1 | 1 |
| α-helix | 55-62 | 8 | |
| α-helix | 66 | 1 | |
| β-strand | 70-74 | 5 | 1 |
| β-strand | 82-88 | 7 | 1 |
| β-strand | 91-100 | 10 | 1 |
| β-strand | 103-106 | 4 | 1 |
| α-helix | 113-115 | 3 | |
| β-strand | 119 | 1 | 1 |
| α-helix | 122-132 | 11 | |
| β-strand | 155 | 1 | 1 |
| α-helix | 160-162 | 3 | |
| α-helix | 163-174 | 12 | |
| α-helix | 178-180 | 3 | |
| α-helix | 185-192 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-9 | 7 | 2 |
| β-strand | 10 | 1 | 3 |
| β-strand | 12-18 | 7 | 2 |
| β-strand | 23 | 1 | 4 |
| α-helix | 24-35 | 12 | |
| α-helix | 39-41 | 3 | |
| β-strand | 42-46 | 5 | 2 |
| β-strand | 49-50 | 2 | 2 |
| α-helix | 51-52 | 2 | |
| β-strand | 56 | 1 | 4 |
| α-helix | 57-60 | 4 | |
| β-strand | 68 | 1 | 5 |
| β-strand | 71 | 1 | 5 |
| α-helix | 72 | 1 | |
| β-strand | 73-79 | 7 | 2 |
| β-strand | 80-81 | 2 | 6 |
| β-strand | 84-85 | 2 | 6 |
| α-helix | 86-88 | 3 | |
| β-strand | 90 | 1 | 3 |
| α-helix | 91-100 | 10 | |
| α-helix | 101-103 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 18-22 | 5 | 2 |
| β-strand | 28-32 | 5 | 2 |
| α-helix | 33-36 | 4 | |
| α-helix | 40-44 | 5 | |
| β-strand | 59-61 | 3 | 2 |
| α-helix | 67-82 | 16 | |
| α-helix | 90-92 | 3 | |
| α-helix | 97-110 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Suppressor of cytokine signaling 2 | A | protein | 169 | HOMO SAPIENS | O14508 (AlphaFold model) |
| Transcription elongation factor B polypeptide 2 | B | protein | 118 | HOMO SAPIENS | Q15370 (AlphaFold model) |
| Transcription elongation factor B polypeptide 1 | C | protein | 97 | HOMO SAPIENS | Q15369 (AlphaFold model) |
>2C9W_1 SUPPRESSOR OF CYTOKINE SIGNALING 2 (chains A) SMQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTS AGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVH LYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV
>2C9W_2 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 (chains B) MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
>2C9W_3 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 (chains C) MMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCM YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
| ID | Name | Formula | Copies |
|---|---|---|---|
| NI | Nickel (II) ion | Ni | 3 |
Water and common crystallization additives (SO4) are not listed.
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Bullock, A.N., Debreczeni, J.E., Edwards, A.M. et al. Proc Natl Acad Sci U S A (2006) 103:7637-7642. DOI 10.1073/pnas.0601638103 · PubMed
Other PDB entries of the same protein (UniProt O14508 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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