2E2R: Estrogen-related receptor gamma

Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol A. Determined by X-ray diffraction at 1.6 Å resolution. Released 11 Sept 2007.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,357
Mol. weight: 28.12 kDa
Ligands: 2OH
Released: 11 Sept 2007

Explore 2E2R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2E2R contains 13 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	236-243	8
α-helix	245-248	4
α-helix	258-259	2
α-helix	261-283	23
α-helix	289-291	3
α-helix	294-316	23
β-strand	324-327	4	1
β-strand	330-332	3	1
α-helix	334-339	6
α-helix	343-359	17
α-helix	363-375	13
α-helix	385-406	22
α-helix	413-418	6
α-helix	421-441	21
α-helix	448-454	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Estrogen-related receptor gamma	A	protein	244	Homo sapiens	P62508 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2E2R_1 Estrogen-related receptor gamma (chains A)
LGSPEFLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRE
LVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDED
QSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVL
HEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE
AKVC

Ligands and cofactors

ID	Name	Formula	Copies
2OH	4,4'-propane-2,2-diyldiphenol	C15 H16 O2	1

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR{gamma}. Matsushima, A., Kakuta, Y., Teramoto, T. et al. J Biochem (2007) 142:517-524. DOI 10.1093/jb/mvm158 · PubMed

Other PDB entries of the same protein (UniProt P62508 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6XXC 1.3 Å, Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD)…
6XY5 1.3 Å, Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD)…
6Y18 1.3 Å, Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD)…
6Y3W 1.34 Å, Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD)…
6Y1D 1.38 Å, Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (DBD)…
8B4Q 1.4 Å, Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5
8BJG 1.4 Å, Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8
8BJN 1.4 Å, Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6
8BM5 1.4 Å, Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7
6I65 1.5 Å, Crystal structure of human ERRg LBD in complex with 4-iso-propylphenol
9KNG 1.5 Å, Crystal structure of human ERRg LBD in complex with 4034496
9KND 1.52 Å, Crystal structure of human ERRg LBD in complex with indole

Browse structure collections

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