Estrogen-related receptor gamma (ESRRG) is a 458-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62508.
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The mean pLDDT of this model is 76.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle
Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6XXC | X-ray | 1.3 Å | B=174-182 |
| 6XY5 | X-ray | 1.3 Å | B=174-182 |
| 6Y18 | X-ray | 1.3 Å | B=174-182 |
| 6Y3W | X-ray | 1.34 Å | B=174-182 |
| 6Y1D | X-ray | 1.38 Å | B=174-182 |
| 8B4Q | X-ray | 1.4 Å | B=174-182 |
| 8BJG | X-ray | 1.4 Å | B=174-182 |
| 8BJN | X-ray | 1.4 Å | B=174-182 |
| 8BM5 | X-ray | 1.4 Å | B=174-182 |
| 6I65 | X-ray | 1.5 Å | A=222-458 |
| 9KNG | X-ray | 1.5 Å | A=229-458 |
| 9KND | X-ray | 1.52 Å | A=229-458 |
| 2E2R | X-ray | 1.6 Å | A=222-458 |
| 6I66 | X-ray | 1.6 Å | A=222-458 |
| 9KNF | X-ray | 1.62 Å | A=229-458 |
| 6I61 | X-ray | 1.65 Å | A=222-458 |
| 6I62 | X-ray | 1.65 Å | A=222-458 |
| 2GPU | X-ray | 1.7 Å | A=229-458 |
| 2ZKC | X-ray | 1.7 Å | A=222-458 |
| 6I67 | X-ray | 1.75 Å | A=222-458 |
Showing 20 of 43 experimental structures (best resolution first).
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