2EOT: Eotaxin

Solution structure of eotaxin, an ensemble of 32 NMR solution structures. Determined by solution NMR. Released 11 Nov 1998.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 585
Mol. weight: 8.38 kDa
Released: 11 Nov 1998

Explore 2EOT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2EOT contains 2 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-19	3
β-strand	23-29	7	1
β-strand	38-43	6	1
β-strand	48-51	4	1
α-helix	56-68	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Eotaxin	A	protein	74	Homo sapiens	P51671 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2EOT_1 EOTAXIN (chains A)
GPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQD
SMKYLDQKSPTPKP

Primary citation

Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. Crump, M.P., Rajarathnam, K., Kim, K.S. et al. J Biol Chem (1998) 273:22471-22479. DOI 10.1074/jbc.273.35.22471 · PubMed

Other PDB entries of the same protein (UniProt P51671 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SCS 1.51 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11
1EOT Solution NMR structure of eotaxin, minimized average structure
2MPM Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal…

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