2FIB: Fibrinogen

Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411) complexed to the peptide gly-pro-arg-pro at PH 6.0. Determined by X-ray diffraction at 2.01 Å resolution. Released 15 Oct 1997.

Method: X-ray diffraction
Resolution: 2.01 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,149
Mol. weight: 30.71 kDa
Ligands: CA
Released: 15 Oct 1997

Explore 2FIB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2FIB contains 11 α-helices and 20 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	145-150	6	1
α-helix	153-158	6
β-strand	165-169	5	1
β-strand	178-184	7	1
β-strand	190-197	8	1
α-helix	208-213	6
β-strand	215-216	2	1
β-strand	226-227	2	1
α-helix	230-237	8
α-helix	239-241	3
β-strand	244-251	8	1
β-strand	257-263	7	1
β-strand	266-267	2	2
α-helix	270-272	3
β-strand	276-277	2	2
β-strand	280-283	4	1
α-helix	289-291	3
α-helix	301-305	5
α-helix	310-312	3
β-strand	313	1	3
β-strand	314	1	4
β-strand	317	1	4
α-helix	326-330	5
β-strand	334	1	3
β-strand	342-343	2	5
β-strand	353	1	6
α-helix	356-358	3
β-strand	368-369	2	5
β-strand	377	1	6
β-strand	381-388	8	1
α-helix	389-391	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Fibrinogen	A	protein	269	Homo sapiens	P02679 (AlphaFold model)
Gly-pro-arg-pro	B	protein	4

Sequence of entity 1 (A), FASTA

>2FIB_1 FIBRINOGEN (chains A)
VQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSV
DFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADY
AMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKF
EGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKT
TMKIIPFNRLTIGEGQQHHLGGAKQAGDV

Sequence of entity 2 (B), FASTA

>2FIB_2 GLY-PRO-ARG-PRO (chains B)
GPRP

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1

Primary citation

The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Pratt, K.P., Cote, H.C., Chung, D.W. et al. Proc Natl Acad Sci U S A (1997) 94:7176-7181. DOI 10.1073/pnas.94.14.7176 · PubMed

Other PDB entries of the same protein (UniProt P02679 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9KHB 1.03 Å, Crystal structure of wild-type human fibrinogen gamma chain C-terminal domain…
9KHC 1.32 Å, Crystal structure of wild-type human fibrinogen gamma chain C-terminal domain…
2Y7L 1.49 Å, Structure of N-terminal domain of Candida albicans Als9-2 in complex with human…
1DUG 1.8 Å, Structure of the fibrinogen G chain integrin binding and factor xiiia crosslinking sites…
4B60 1.83 Å, Structure of rFnBPA(189-505) in complex with fibrinogen gamma chain C- terminal peptide
2VR3 1.95 Å, Structural and Biochemical Characterization of Fibrinogen binding to ClfA from…
1FIB 2.1 Å, Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411) bound…
1FID 2.1 Å, Structure of human gamma fibrinogen 30 kd carboxyl terminal fragment
3FIB 2.1 Å, Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411) bound…
1FZC 2.3 Å, Crystal structure of fragment double-D from human fibrin with two different bound ligands
3E1I 2.3 Å, Crystal Structure of BbetaD432A Variant Fibrinogen Fragment D with the Peptide Ligand…
2HWL 2.4 Å, Crystal structure of thrombin in complex with fibrinogen gamma' peptide

Browse structure collections

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