Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2). Determined by X-ray diffraction at 1.7 Å resolution. Released 13 Jun 2006.
Explore 2G19 in 3D Show helices and sheets RCSB PDB PDBe
2G19 contains 8 α-helices and 17 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 190-193 | 4 | |
| α-helix | 194-198 | 5 | |
| α-helix | 199-205 | 7 | |
| β-strand | 207-210 | 4 | 1 |
| α-helix | 216-231 | 16 | |
| β-strand | 240-242 | 3 | 2 |
| α-helix | 247-249 | 3 | |
| β-strand | 251-252 | 2 | 2 |
| β-strand | 255-259 | 5 | 1 |
| α-helix | 267-283 | 17 | |
| β-strand | 292-295 | 4 | 1 |
| β-strand | 298-303 | 6 | 1 |
| β-strand | 310-313 | 4 | 3 |
| β-strand | 322-329 | 8 | 1 |
| β-strand | 331 | 1 | 4 |
| α-helix | 336-339 | 4 | |
| β-strand | 340 | 1 | 5 |
| β-strand | 343-345 | 3 | 3 |
| β-strand | 354-356 | 3 | 3 |
| β-strand | 359 | 1 | 4 |
| β-strand | 362-367 | 6 | 1 |
| β-strand | 374-376 | 3 | 3 |
| β-strand | 379 | 1 | 5 |
| β-strand | 383-392 | 10 | 1 |
| α-helix | 393-399 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Egl nine homolog 1 | A | protein | 244 | Homo sapiens | Q9GZT9 (AlphaFold model) |
>2G19_1 Egl nine homolog 1 (chains A) MPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQ LVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAM VACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPK FDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPHH HHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| 4HG | N-[(4-hydroxy-8-iodoisoquinolin-3-yl)carbonyl]glycine | C12 H9 I N2 O4 | 1 |
| FE2 | FE (II) ion | Fe | 1 |
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). McDonough, M.A., Li, V., Flashman, E. et al. Proc Natl Acad Sci U S A (2006) 103:9814-9819. DOI 10.1073/pnas.0601283103 · PubMed
Other PDB entries of the same protein (UniProt Q9GZT9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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