2HYD: Multidrug ABC transporter SAV1866

Multidrug ABC transporter SAV1866. Determined by X-ray diffraction at 3.0 Å resolution. Released 5 Sept 2006.

Method
X-ray diffraction
Resolution
3.0 Å
Organism
Staphylococcus aureus
Chains
2
Atoms
9,240
Mol. weight
130.77 kDa
Ligands
ADP
Released
5 Sept 2006

Explore 2HYD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2HYD contains 76 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 12 β-strands

ElementResiduesLengthSheet
α-helix2-98
α-helix10-123
α-helix13-2412
α-helix28-3811
α-helix39-457
α-helix52-6817
α-helix69-735
α-helix74-10633
α-helix109-1135
α-helix117-1226
α-helix123-1275
α-helix128-1303
α-helix132-1332
α-helix134-1418
α-helix142-15918
α-helix164-1674
α-helix170-21546
α-helix219-27254
α-helix277-2859
α-helix287-2904
α-helix293-31826
α-helix320-3223
β-strand340-34781
α-helix354-3552
β-strand357-36481
β-strand369-37352
α-helix380-3845
β-strand395-40061
β-strand403-40421
α-helix405-4073
α-helix410-4156
β-strand417-42042
β-strand43013
α-helix431-4355
α-helix436-4383
α-helix444-45310
α-helix457-4615
α-helix466-4683
β-strand47013
α-helix471-4722
α-helix473-4753
α-helix480-49415
β-strand498-50252
α-helix510-52314
β-strand528-53252
α-helix536-5383
β-strand544-54962
β-strand552-55762
α-helix559-5646
α-helix568-5736
Chain B: 38 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix2-98
α-helix10-123
α-helix13-2412
α-helix28-4013
α-helix41-455
α-helix55-584
α-helix62-687
α-helix69-735
α-helix74-10633
α-helix109-1135
α-helix117-1226
α-helix123-1275
α-helix128-1303
α-helix132-1332
α-helix134-1418
α-helix142-15918
α-helix161-1688
α-helix170-21546
α-helix219-27052
α-helix279-29012
α-helix293-31826
α-helix320-3223
β-strand340-34784
α-helix354-3552
β-strand357-36484
β-strand369-37355
α-helix380-3845
β-strand395-40064
β-strand403-40424
α-helix405-4073
α-helix410-4156
β-strand417-42045
β-strand43016
α-helix431-4355
α-helix436-4383
α-helix444-45310
α-helix457-4615
α-helix466-4683
β-strand47016
α-helix471-4722
α-helix473-4753
α-helix480-49415
β-strand498-50255
α-helix510-52314
β-strand528-53255
α-helix536-5383
β-strand544-54965
β-strand552-55765
α-helix559-5646
α-helix568-5736

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
ABC transporter homologA, Bprotein578Staphylococcus aureusQ99T13 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>2HYD_1 ABC transporter homolog (chains A, B)
MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLT
IAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQV
ISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYV
FFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKH
TRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVAS
FTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDI
NLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLV
QQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSG
GQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTIT
HADKIVVIENGHIVETGTHRELIAKQGAYEHLYSIQNL

Ligands and cofactors

IDNameFormulaCopies
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P22

Water and common crystallization additives (NA) are not listed.

Primary citation

Structure of a bacterial multidrug ABC transporter. Dawson, R.J., Locher, K.P. Nature (2006) 443:180-185. DOI 10.1038/nature05155 · PubMed

Other PDB entries of the same protein (UniProt Q99T13 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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