2JDQ: Importin alpha-1 subunit

C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5. Determined by X-ray diffraction at 2.2 Å resolution. Released 27 Feb 2007.

Method
X-ray diffraction
Resolution
2.2 Å
Organisms
HOMO SAPIENS, INFLUENZA A VIRUS
Chains
4
Atoms
7,862
Mol. weight
117.35 kDa
Released
27 Feb 2007

Explore 2JDQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2JDQ contains 76 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 32 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix85-928
α-helix96-11116
α-helix118-1225
α-helix127-1359
α-helix141-15515
α-helix159-1679
α-helix170-1778
α-helix183-19715
α-helix201-2099
α-helix213-2197
α-helix226-24015
α-helix246-2483
α-helix249-2513
α-helix253-2553
α-helix256-2627
α-helix268-28114
α-helix286-2949
α-helix298-3047
α-helix310-32314
α-helix328-3358
α-helix339-3468
α-helix352-36514
α-helix370-3789
α-helix381-39111
α-helix394-41017
α-helix413-42210
α-helix425-4306
α-helix431-4333
α-helix437-46024
α-helix467-47610
α-helix478-4858
α-helix487-50418
Chain B: 32 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix85-917
α-helix96-10914
α-helix118-1225
α-helix128-1347
α-helix141-15515
α-helix159-1679
α-helix170-1778
α-helix183-19715
α-helix201-2099
α-helix213-2186
α-helix226-24015
α-helix246-2483
α-helix249-2524
α-helix253-2553
α-helix256-2627
α-helix268-28114
α-helix286-2949
α-helix298-3036
α-helix304-3063
α-helix310-32314
α-helix328-3358
α-helix339-3468
α-helix352-36514
α-helix370-3789
α-helix382-39110
α-helix394-41017
α-helix413-4219
α-helix425-4317
α-helix437-46024
α-helix467-47610
α-helix478-4858
α-helix487-50317
Chain D: 6 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix691-6933
β-strand694-69961
α-helix702-7043
α-helix7071
β-strand70811
α-helix7091
α-helix712-7154
α-helix7171
β-strand721-72771
β-strand730-73671
Chain E: 6 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix687-6915
β-strand694-69962
α-helix702-7043
α-helix7071
β-strand70812
α-helix7091
α-helix713-7153
α-helix7171
β-strand722-72762
β-strand730-73672

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin alpha-1 subunitA, Bprotein450HOMO SAPIENSP52294 (AlphaFold model)
Polymerase basic protein 2D, Eprotein83INFLUENZA A VIRUSP31345
Sequence of entity 1 (A, B), FASTA
>2JDQ_1 IMPORTIN ALPHA-1 SUBUNIT (chains A, B)
GAMGFHEAQINNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVI
STPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEF
EDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRG
KSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLV
ELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTI
SNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVEL
GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE
FLQSHENQEIYQKAFDLIEHYFGTEDEDSS
Sequence of entity 2 (D, E), FASTA
>2JDQ_2 POLYMERASE BASIC PROTEIN 2 (chains D, E)
GDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMK
RKRDSSILTDSQTATKRIRMAIN

Primary citation

Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit. Tarendeau, F., Boudet, J., Guilligay, D. et al. Nat Struct Mol Biol (2007) 14:229. DOI 10.1038/NSMB1212 · PubMed

Other PDB entries of the same protein (UniProt P52294 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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