2JK9: Spry domain-containing socs box protein 1

The structure of splA-ryanodine receptor domain and SOCS box containing 1 in complex with a PAR-4 peptide. Determined by X-ray diffraction at 1.79 Å resolution. Released 16 Sept 2008.

Method: X-ray diffraction
Resolution: 1.79 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 1,792
Mol. weight: 25.51 kDa
Released: 16 Sept 2008

Explore 2JK9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2JK9 contains 5 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	36-42	7
α-helix	44-47	4
α-helix	48-53	6
β-strand	56-61	6	1
β-strand	65-68	4	2
β-strand	71-77	7	2
β-strand	80	1	3
β-strand	83-89	7	1
β-strand	93	1	4
β-strand	97-103	7	2
α-helix	106-108	3
β-strand	114-118	5	1
β-strand	125-127	3	1
β-strand	139-143	5	1
β-strand	148-151	4	1
β-strand	159-160	2	1
α-helix	172-174	3
β-strand	176-182	7	2
β-strand	187-192	6	2
β-strand	195-201	7	2
β-strand	209	1	4
β-strand	210-215	6	1
β-strand	221-230	10	2

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	7	1	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Spry domain-containing socs box protein 1	A	protein	212	HOMO SAPIENS	Q96BD6 (AlphaFold model)
Prkc apoptosis WT1 regulator protein	B	protein	15	HOMO SAPIENS	Q96IZ0 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2JK9_1 SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1 (chains A)
SMQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVA
QSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWG
WDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAF
RGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPE

Sequence of entity 2 (B), FASTA

>2JK9_2 PRKC APOPTOSIS WT1 REGULATOR PROTEIN (chains B)
NELNNNLPGGAPAAP

Primary citation

Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4. Filippakopoulos, P., Low, A., Sharpe, T.D. et al. J Mol Biol (2010) 401:389. DOI 10.1016/J.JMB.2010.06.017 · PubMed

Other PDB entries of the same protein (UniProt Q96BD6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3F2O 2.05 Å, Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 1…

Browse structure collections

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