2KBV: Sodium/hydrogen exchanger 1

Structural and functional analysis of TM XI of the NHE1 isoform of thE NA+/H+ exchanger. Determined by solution NMR. Released 27 Jan 2009.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 206
Mol. weight: 2.89 kDa
Released: 27 Jan 2009

Explore 2KBV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2KBV contains 3 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	448-450	3
α-helix	451-455	5
α-helix	459-471	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sodium/hydrogen exchanger 1	A	protein	28	Homo sapiens	P19634 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2KBV_1 Sodium/hydrogen exchanger 1 (chains A)
XKDQFIIAYGGLRGAIAFSLGYLLDKKX

Primary citation

Structural and Functional Analysis of Transmembrane XI of the NHE1 Isoform of the Na+/H+ Exchanger. Lee, B.L., Li, X., Liu, Y. et al. J Biol Chem (2009) 284:11546-11556. DOI 10.1074/jbc.M809201200 · PubMed

Other PDB entries of the same protein (UniProt P19634 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6NUC 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
6NUF 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
9NXE 2.09 Å, Crystal Structure of Calcineurin Clinical Variant E282K
2YGG 2.23 Å, Complex of CaMBR and CaM
6NUU 2.3 Å, Structure of Calcineurin mutant in complex with NHE1 peptide
2BEC 2.7 Å, Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into…
23XI 2.93 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Zoniporide in…
23XK 3.1 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in…
23XO 3.16 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in…
23XM 3.24 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Eniporide in an…
7DSW 3.3 Å, Structure of a human NHE1-CHP1 complex under pH 7.5
7DSV 3.4 Å, Structure of a human NHE1-CHP1 complex under pH 6.5

Browse structure collections

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