2L0E: Sodium/hydrogen exchanger 1

Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger. Determined by solution NMR. Released 15 Sept 2010.

Method

Solution NMR

Organism

Homo sapiens

Chains

1

Atoms

246

Mol. weight

3.47 kDa

Released

15 Sept 2010

Explore 2L0E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2L0E contains 2 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Molecules and chains

>2L0E_1 Sodium/hydrogen exchanger 1 (chains A)
XKKKDNLLFGSIISAVDPVAVLAVFEEIHKKKX

Primary citation

Structural and Functional Analysis of Transmembrane Segment VI of the NHE1 Isoform of the Na+/H+ Exchanger. Tzeng, J., Lee, B.L., Sykes, B.D. et al. J Biol Chem (2010) 285:36656-36665. DOI 10.1074/jbc.M110.161471 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P19634 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6NUC 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
• 6NUF 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
• 9NXE 2.09 Å, Crystal Structure of Calcineurin Clinical Variant E282K
• 2YGG 2.23 Å, Complex of CaMBR and CaM
• 6NUU 2.3 Å, Structure of Calcineurin mutant in complex with NHE1 peptide
• 2BEC 2.7 Å, Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into…
• 23XI 2.93 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Zoniporide in…
• 23XK 3.1 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in…
• 23XO 3.16 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in…
• 23XM 3.24 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Eniporide in an…
• 7DSW 3.3 Å, Structure of a human NHE1-CHP1 complex under pH 7.5
• 7DSV 3.4 Å, Structure of a human NHE1-CHP1 complex under pH 6.5

Browse structure collections

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