2LEF: LEF1 hmg domain (from mouse)

LEF1 hmg domain (from mouse), complexed with DNA (15BP), NMR, 12 structures. Determined by solution NMR. Released 21 Oct 1998.

Method: Solution NMR
Organism: Mus musculus
Chains: 3
Atoms: 1,337
Mol. weight: 19.58 kDa
Released: 21 Oct 1998

Explore 2LEF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LEF contains 3 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	9-24	16
α-helix	30-41	12
α-helix	46-66	21

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA (5'-d(cpapcpcpcptptptpgpapapgpcptp*c)-3')	B	DNA	15
DNA (5'-d(gpapgpcptptpcpapapapgpgpgptp*g)-3')	C	DNA	15
Protein (lymphoid enhancer-binding factor)	A	protein	86	Mus musculus	P27782 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>2LEF_1 DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)-3') (chains B)
CACCCTTTGAAGCTC

Sequence of entity 2 (C), FASTA

>2LEF_2 DNA (5'-D(*GP*AP*GP*CP*TP*TP*CP*AP*AP*AP*GP*GP*GP*TP*G)-3') (chains C)
GAGCTTCAAAGGGTG

Sequence of entity 3 (A), FASTA

>2LEF_3 PROTEIN (LYMPHOID ENHANCER-BINDING FACTOR) (chains A)
MHIKKPLNAFMLYMKEMRANVVAESTLKESAAINQILGRRWHALSREEQAKYYELARKER
QLHMQLYPGWSARDNYGKKKKRKREK

Primary citation

Structural basis for DNA bending by the architectural transcription factor LEF-1. Love, J.J., Li, X., Case, D.A. et al. Nature (1995) 376:791-795. DOI 10.1038/376791a0 · PubMed

Other PDB entries of the same protein (UniProt P27782 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3OUX 2.4 Å, Structure of beta-catenin with phosphorylated Lef-1
3OUW 2.91 Å, Structure of beta-catenin with Lef-1

Browse structure collections

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