3OUW: Beta-catenin with Lef-1

Structure of beta-catenin with Lef-1. Determined by X-ray diffraction at 2.91 Å resolution. Released 24 Nov 2010.

Method: X-ray diffraction
Resolution: 2.91 Å
Organism: Mus musculus
Chains: 2
Atoms: 3,963
Mol. weight: 65.82 kDa
Released: 24 Nov 2010

Explore 3OUW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3OUW contains 38 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 35 helices, 0 β-strands

Element	Residues	Length
α-helix	168-172	5
α-helix	182-189	8
α-helix	192-204	13
α-helix	210-221	12
α-helix	225-232	8
α-helix	236-242	7
α-helix	249-265	17
α-helix	269-275	7
α-helix	278-284	7
α-helix	291-305	15
α-helix	309-318	10
α-helix	320-330	11
α-helix	334-347	14
α-helix	353-359	7
α-helix	362-366	5
α-helix	375-388	14
α-helix	391-394	4
α-helix	399-408	10
α-helix	414-427	14
α-helix	432-440	9
α-helix	443-452	10
α-helix	458-471	14
α-helix	478-487	10
α-helix	491-496	6
α-helix	504-517	14
α-helix	521-523	3
α-helix	524-528	5
α-helix	532-543	12
α-helix	566-580	15
α-helix	584-591	8
α-helix	596-602	7
α-helix	608-621	14
α-helix	625-633	9
α-helix	637-643	7
α-helix	649-661	13

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	17-20	4
α-helix	49-53	5
α-helix	54-56	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Catenin beta-1	A	protein	540	Mus musculus	Q02248 (AlphaFold model)
Lymphoid enhancer-binding factor 1	B	protein	65	Mus musculus	P27782 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3OUW_1 Catenin beta-1 (chains A)
GSHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRS
PQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSV
LFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQES
KLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLT
DPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNN
YKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGL
PVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRT
SMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQ
RVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYK

Sequence of entity 2 (B), FASTA

>3OUW_2 Lymphoid enhancer-binding factor 1 (chains B)
GAMPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE
SEIIP

Primary citation

Biochemical and structural characterization of beta-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. Sun, J., Weis, W.I. J Mol Biol (2011) 405:519-530. DOI 10.1016/j.jmb.2010.11.010 · PubMed

Other PDB entries of the same protein (UniProt Q02248 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1DOW 1.8 Å, Crystal structure of a chimera of beta-catenin and alpha-catenin
4EV8 1.9 Å, Crystal structure of mouse catenin beta-59 in 2.4M urea.
1I7W 2.0 Å, Beta-catenin/phosphorylated E-cadherin complex
4EVA 2.0 Å, Crystal Structure of Mouse Catenin beta-59 in 5.6M urea
1M1E 2.1 Å, Beta-catenin armadillo repeat domain bound to ICAT
1V18 2.1 Å, The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated…
3BCT 2.1 Å, The armadillo repeat region from murine beta-catenin
4EV9 2.1 Å, Crystal Structure of Mouse Catenin beta-59 in 4.0M urea
4EVP 2.25 Å, Crystal Structure of Mouse Catenin beta-59 in 7.2M urea
4EVT 2.34 Å, Crystal Structure of Mouse Catenin beta-59 in 8.3M urea
3OUX 2.4 Å, Structure of beta-catenin with phosphorylated Lef-1
4ONS 2.8 Å, Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin…

Browse structure collections

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