2LK9: BST-2/Tetherin Transmembrane Domain

Structure of BST-2/Tetherin Transmembrane Domain. Determined by solution NMR. Released 9 Nov 2011.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 96
Mol. weight: 3.92 kDa
Released: 9 Nov 2011

Explore 2LK9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LK9 contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	23-44	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bone marrow stromal antigen 2	A	protein	35	Homo sapiens	Q10589 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2LK9_1 Bone marrow stromal antigen 2 (chains A)
KRSKLLLGIGILVLLIIVILGVPLIIFTIKKKKKK

Primary citation

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions. Skasko, M., Wang, Y., Tian, Y. et al. J Biol Chem (2012) 287:58-67. DOI 10.1074/jbc.M111.296772 · PubMed

Other PDB entries of the same protein (UniProt Q10589 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Q9A 2.1 Å, MHC Class I A02 Allele presenting LLLGIGILVL, in complex with Mel5 TCR
3MQ7 2.28 Å, Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317
3NWH 2.6 Å, Crystal structure of BST2/Tetherin
2X7A 2.77 Å, Structural basis of HIV-1 tethering to membranes by the Bst2-tetherin ectodomain
3MQ9 2.8 Å, Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317 Fused to MBP
3MQC 2.8 Å, Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21)
4P6Z 3.0 Å, Crystal structure of the human BST2 cytoplasmic domain and the HIV-1 Vpu cytoplasmic…
3MQB 3.2 Å, Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (C2)
2XG7 3.45 Å, Crystal Structure of BST2-Tetherin Ectodomain expressed in HEK293T cells
6CM9 3.73 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit
6DFF 3.9 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer
6D83 4.27 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant…

Browse structure collections

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