2MJ8: CDYL2 chromodomain

Solution structure of CDYL2 chromodomain. Determined by solution NMR. Released 23 Apr 2014.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 543
Mol. weight: 7.7 kDa
Released: 23 Apr 2014

Explore 2MJ8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MJ8 contains 3 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	9-17	9	1
β-strand	23-29	7	1
α-helix	33-36	4
β-strand	38-41	4	1
α-helix	42-44	3
α-helix	50-58	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Chromodomain Y-like protein 2	A	protein	64	Homo sapiens	Q8N8U2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2MJ8_1 Chromodomain Y-like protein 2 (chains A)
GASGDLYEVERIVDKRKNKKGKWEYLIRWKGYGSTEDTWEPEHHLLHCEEFIDEFNGLHM
SKDK

Primary citation

Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Dong, C., Liu, Y., Lyu, T.J. et al. Cell Chem Biol (2020) 27:827-838.e7. DOI 10.1016/j.chembiol.2020.05.007 · PubMed

Other PDB entries of the same protein (UniProt Q8N8U2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8SP6 1.45 Å, Complex structure of CDYL2 with an antagonist
4HAE 2.0 Å, Crystal structure of the CDYL2-chromodomain
5JJZ 2.0 Å, Chromo domain of human Chromodomain Protein, Y-Like 2
6V2D 2.1 Å, Crystal Structure of chromodomain of CDYL2 in complex with inhibitor UNC3866
6V2H 2.6 Å, Crystal structure of CDYL2 in complex with H3tK27me3
6V3N 2.7 Å, Crystal structure of CDYL2 in complex with H3K27me3
6V8W 2.8 Å, CDYL2 chromodomain in complex with a synthetic peptide

Browse structure collections

About this viewer

MolViewer shows 2MJ8 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.