Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of Gly12-Ile13-Gly14-Thr15. Determined by solution NMR. Released 2 Jul 2014.
Explore 2MMT in 3D Show helices and sheets RCSB PDB PDBe
2MMT contains 0 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-7 | 6 | 1 |
| β-strand | 19 | 1 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Microcin J25 RGDF mutant | A | protein | 21 | Escherichia coli | Q9X2V7 (AlphaFold model) |
>2MMT_1 Microcin J25 RGDF mutant (chains A) GGAGHVPEYFVRGDFPISFYG
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. Hegemann, J.D., De Simone, M., Zimmermann, M. et al. J Med Chem (2014) 57:5829-5834. DOI 10.1021/jm5004478 · PubMed
Other PDB entries of the same protein (UniProt Q9X2V7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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