Lasso peptide based integrin inhibitor: microcin J25 variant with rgd substitution of GLY12-ILE13-GLY14. Determined by solution NMR. Released 14 May 2014.
Explore 2MMW in 3D Show helices and sheets RCSB PDB PDBe
2MMW contains 0 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-7 | 6 | 1 |
| β-strand | 19 | 1 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Microcin J25 | A | protein | 21 | Escherichia coli | Q9X2V7 (AlphaFold model) |
>2MMW_1 Microcin J25 (chains A) GGAGHVPEYFVRGDTPISFYG
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Knappe, T.A., Manzenrieder, F., Mas-Moruno, C. et al. Angew Chem Int Ed Engl (2011) 50:8714-8717. DOI 10.1002/anie.201102190 · PubMed
Other PDB entries of the same protein (UniProt Q9X2V7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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