2MRF: E3 ubiquitin-protein ligase RAD18

Name: PDB 2MRF: NMR structure of the ubiquitin-binding zinc finger (UBZ) domain from human Rad18
Published: 2014-10-01
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ligase

NMR structure of the ubiquitin-binding zinc finger (UBZ) domain from human Rad18. Determined by solution NMR. Released 1 Oct 2014.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 252
Mol. weight: 3.69 kDa
Ligands: ZN
Released: 1 Oct 2014

Explore 2MRF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MRF contains 1 α-helix and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	201-203	3	1
β-strand	210-212	3	1
α-helix	213-223	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase RAD18	A	protein	33	Homo sapiens	Q9NS91 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2MRF_1 E3 ubiquitin-protein ligase RAD18 (chains A)
GSRQVTKVDCPVCGVNIPESHINKHLDSCLSRE

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

NMR Structure of the Human Rad18 Zinc Finger in Complex with Ubiquitin Defines a Class of UBZ Domains in Proteins Linked to the DNA Damage Response. Rizzo, A.A., Salerno, P.E., Bezsonova, I. et al. Biochemistry (2014) 53:5895-5906. DOI 10.1021/bi500823h · PubMed

Other PDB entries of the same protein (UniProt Q9NS91 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8IR4 1.62 Å, Crystal structure of the SLF1 BRCT domain in complex with a Rad18 peptide containing pS442
8IR2 1.75 Å, Crystal structure of the SLF1 BRCT domain in complex with a Rad18 peptide containing…
2Y43 1.8 Å, Rad18 ubiquitin ligase RING domain structure
2YBF 2.0 Å, Complex of Rad18 (Rad6 binding domain) with Rad6b
9BD3 2.58 Å, Structure of the MAGEA4 MHD-RAD18 R6BD Complex
2MRE NMR structure of the Rad18-UBZ/ubiquitin complex
5VF0 Solution NMR structure of human RAD18 (198-240) in complex with ubiquitin

Browse structure collections

About this viewer

MolViewer shows 2MRF directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.