2PKG: PDB entry 2PKG

Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40. Determined by X-ray diffraction at 3.3 Å resolution. Released 15 May 2007.

Method

X-ray diffraction

Resolution

3.3 Å

Organisms

Homo sapiens, Simian virus 40

Chains

4

Atoms

10,358

Mol. weight

150.28 kDa

Ligands

ZN

Released

15 May 2007

Explore 2PKG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2PKG contains 127 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 55 helices, 0 β-strands

Molecules and chains

>2PKG_1 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (chains A, B)
LYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLAL
AEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFV
PLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKL
GEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLR
QAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEF
CENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLF
LAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPL
LAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAM
SGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGP
ILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA

>2PKG_2 Small T antigen (chains C, D)
SLNPGVDAMYCKQWPECAKKMSANCICLLCLLRMKHENRKLYRKDPLVWVDCYCFDCFRM
WFGLDLCEGTLLLWCDIIGQTTYRDLKL

Ligands and cofactors

Primary citation

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Chen, Y., Xu, Y., Bao, Q. et al. Nat Struct Mol Biol (2007) 14:527-534. DOI 10.1038/nsmb1254 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P30153 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 1B3U 2.3 Å, Crystal structure of constant regulatory domain of human PP2A, PR65ALPHA
• 4I5L 2.43 Å, Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6…
• 8TWE 2.55 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
• 2IE4 2.6 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
• 9C6B 2.6 Å, PP2A:B55-p107 substrate complex
• 8TWI 2.69 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
• 8U1X 2.7 Å, The structure of the PP2A-B56Delta holoenzyme mutant - E197K
• 9C7T 2.7 Å, PP2A:B55-Eya3 substrate complex
• 8TTB 2.77 Å, Cryo-EM structure of the PP2A:B55-ARPP19 complex
• 8SO0 2.8 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex
• 2IE3 2.8 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
• 3C5W 2.8 Å, Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme

Browse structure collections

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