2PXY: Immune receptor complexes

Crystal structures of immune receptor complexes. Determined by X-ray diffraction at 2.23 Å resolution. Released 9 Oct 2007.

Method: X-ray diffraction
Resolution: 2.23 Å
Organism: Mus musculus
Chains: 5
Atoms: 5,212
Mol. weight: 69.39 kDa
Released: 9 Oct 2007

Explore 2PXY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2PXY contains 16 α-helices and 55 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	1
β-strand	9-13	5	2
β-strand	18-20	3	3
β-strand	22-25	4	1
β-strand	31-37	7	2
β-strand	44-49	6	2
β-strand	55-58	4	3
β-strand	62-65	4	3
β-strand	67	1	1
β-strand	72	1	1
β-strand	75-77	3	3
α-helix	82-84	3
β-strand	86-93	8	2
α-helix	103-104	2
β-strand	105-106	2	2
β-strand	110-115	6	2

Chain B: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	4
β-strand	10-13	4	2
β-strand	19-21	3	5
β-strand	22-25	4	4
β-strand	31-38	8	2
β-strand	42-49	8	2
β-strand	56-57	2	2
β-strand	66-68	3	5
β-strand	74	1	4
β-strand	76-79	4	5
α-helix	84-86	3
β-strand	88-95	8	2
α-helix	104-106	3
β-strand	107-108	2	2
β-strand	112-116	5	2

Chain C: 3 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	5-15	12	6
β-strand	19-26	8	6
β-strand	29-35	7	6
β-strand	40-43	4	6
α-helix	46-49	4
α-helix	56-76	21
β-strand	88-93	6	7
β-strand	103-112	10	7
β-strand	118-123	6	8
β-strand	126-127	2	8
β-strand	132-134	3	7
α-helix	137	1
β-strand	138-139	2	7
β-strand	145-153	9	7
β-strand	161-166	6	8
β-strand	174-178	5	8

Chain D: 9 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	7-18	12	6
β-strand	23-32	10	6
β-strand	35-41	7	6
β-strand	46-49	4	6
α-helix	52-54	3
α-helix	55-64	10
α-helix	68-74	7
α-helix	75-80	6
α-helix	81-82	2
α-helix	83-86	5
α-helix	90-92	3
β-strand	95	1	9
α-helix	96-97	2
β-strand	98-103	6	10
β-strand	113-122	10	10
β-strand	123	1	9
β-strand	128-133	6	11
β-strand	136-138	3	11
β-strand	142-144	3	10
α-helix	146-147	2
β-strand	148-149	2	10
β-strand	155-163	9	10
β-strand	170-176	7	11
β-strand	184-189	6	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T cell receptor alpha chain	A	protein	114	Mus musculus	Q5R1F5 (AlphaFold model)
T cell receptor beta chain	B	protein	111	Mus musculus	A2NTY6 (AlphaFold model)
H-2 class II histocompatibility antigen, A-U alpha chain	C	protein	183	Mus musculus	P14438 (AlphaFold model)
H-2 class II histocompatibility antigen, A-U beta chain	D	protein	189	Mus musculus	P06344 (AlphaFold model)
Myelin basic protein (MBP)-peptide	P	protein	13

Sequence of entity 1 (A), FASTA

>2PXY_1 T cell receptor alpha chain (chains A)
SADSVTQTGGQVALSEEDFLTIHCNYSASGYPALFWYVQYPGEGPQFLFRASRDKEKGSS
RGFEATYNKEATSFHLQKASVQESDSAVYYCALSENYGNEKITFGAGTKLQVVP

Sequence of entity 2 (B), FASTA

>2PXY_2 T cell receptor beta chain (chains B)
AVTQSPRNKVAVTGEKVTLSCNQTNNHNNMYWYRQDTGHGLRLIYYSYGAGSTEKGDIPD
GYKASRPSQENFSLTLESATPSQTSVYFCASGDASGAETLYFGPGTRLTVL

Sequence of entity 3 (C), FASTA

>2PXY_3 H-2 class II histocompatibility antigen, A-U alpha chain (chains C)
DDIEADHVGSYGIVVYQSPGDIGQYTFEFDGDELFYVDLDKKETIWMLPEFAQLRSFDPQ
GGLQNIATGKHNLGVLTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVI
NITWLRNSKSVADGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKH
WEP

Sequence of entity 4 (D), FASTA

>2PXY_4 H-2 class II histocompatibility antigen, A-U beta chain (chains D)
DSERHFVVQFQPFCYFTNGTQRIRYVTRYIYNREEYLRFDSDVGEYRAVTELGRPDAEYY
NKQYLERTRAELDTVCRYNYEETEVPTSLRRLEQPNVVISLSRTEALNHHNTLVCSVTDF
YPAKIKVRWFRNGQEETVGVSSTQLIRNGDWTFQVLVMLEMTPRRGEVYTCHVEHPSLKS
PITVEWRAQ

Sequence of entity 5 (P), FASTA

>2PXY_5 Myelin basic protein (MBP)-peptide (chains P)
HSRGGASQYRPSQ

Primary citation

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Feng, D., Bond, C.J., Ely, L.K. et al. Nat Immunol (2007) 8:975-983. DOI 10.1038/ni1502 · PubMed

Other PDB entries of the same protein (UniProt Q5R1F5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2Z35 2.2 Å, Crystal structure of immune receptor
2Z31 2.7 Å, Crystal structure of immune receptor complex

Browse structure collections

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