2VRR: SUMO modified Ubc9

Structure of SUMO modified Ubc9. Determined by X-ray diffraction at 2.22 Å resolution. Released 19 Aug 2008.

Method: X-ray diffraction
Resolution: 2.22 Å
Organisms: MUS MUSCULUS, HOMO SAPIENS
Chains: 2
Atoms: 2,175
Mol. weight: 27.47 kDa
Released: 19 Aug 2008

Explore 2VRR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2VRR contains 10 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	3-18	16
β-strand	25-30	6	1
α-helix	31	1
β-strand	36-46	11	1
α-helix	47-48	2
β-strand	57-63	7	1
α-helix	72-73	2
β-strand	74-77	4	1
β-strand	86	1	2
β-strand	91	1	1
β-strand	92	1	2
α-helix	95-97	3
α-helix	109-121	13
α-helix	131-139	9
α-helix	141-154	14

Chain B: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	21-27	7	3
β-strand	33-39	7	3
α-helix	45-55	11
α-helix	59-61	3
β-strand	62-66	5	3
β-strand	69-70	2	3
β-strand	86-92	7	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sumo-conjugating enzyme UBC9	A	protein	158	MUS MUSCULUS	P63280 (AlphaFold model)
Small ubiquitin-related modifier 1	B	protein	79	HOMO SAPIENS	P63165 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2VRR_1 SUMO-CONJUGATING ENZYME UBC9 (chains A)
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Sequence of entity 2 (B), FASTA

>2VRR_2 SMALL UBIQUITIN-RELATED MODIFIER 1 (chains B)
MEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPK
ELGMEEEDVIEVYQEQTGG

Primary citation

Ubc9 sumoylation regulates SUMO target discrimination. Knipscheer, P., Flotho, A., Klug, H. et al. Mol Cell (2008) 31:371-382. DOI 10.1016/j.molcel.2008.05.022 · PubMed

Other PDB entries of the same protein (UniProt P63280 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2UYZ 1.4 Å, Non-covalent complex between Ubc9 and SUMO1
1U9A 2.0 Å, Human ubiquitin-conjugating enzyme UBC9
1U9B 2.0 Å, Murine/human ubiquitin-conjugating enzyme UBC9

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