2VUM: DNA-directed RNA polymerase II subunit RPB1

Alpha-amanitin inhibited complete RNA polymerase II elongation complex. Determined by X-ray diffraction at 3.4 Å resolution. Released 17 Jun 2008.

Method: X-ray diffraction
Resolution: 3.4 Å
Organisms: SACCHAROMYCES CEREVISIAE, AMANITA PHALLOIDES, synthetic construct
Chains: 16
Atoms: 32,083
Mol. weight: 531.5 kDa
Ligands: MG, ZN
Released: 17 Jun 2008

Explore 2VUM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2VUM contains 162 α-helices and 224 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 68 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	10	1
β-strand	11	1	1
β-strand	16-18	3	2
β-strand	21	1	3
α-helix	24-30	7
β-strand	82	1	4
β-strand	85-91	7	5
α-helix	96-103	8
β-strand	106	1	6
β-strand	113	1	6
α-helix	120-127	8
α-helix	131-142	12
β-strand	147	1	7
β-strand	151-152	2	8
β-strand	162-163	2	8
β-strand	170	1	7
α-helix	171-172	2
β-strand	173-177	5	9
β-strand	180-184	5	9
β-strand	199-201	3	9
α-helix	204-213	10
α-helix	216-219	4
β-strand	225	1	10
β-strand	229	1	10
α-helix	231-234	4
β-strand	235-238	4	5
β-strand	241	1	4
α-helix	262-265	4
α-helix	267-277	11
α-helix	290-304	15
α-helix	325-328	4
α-helix	336-340	5
β-strand	344	1	11
β-strand	348-355	8	12
β-strand	363-367	5	12
α-helix	368-371	4
β-strand	375-379	5	13
α-helix	385-393	9
β-strand	402-407	6	13
β-strand	411-414	4	13
β-strand	428	1	14
β-strand	430	1	14
β-strand	431-435	5	13
α-helix	436	1
β-strand	442-445	4	12
α-helix	452-454	3
β-strand	455-463	9	12
β-strand	467-470	4	12
α-helix	475-478	4
β-strand	486-490	5	12
α-helix	495-504	10
β-strand	506	1	12
α-helix	507-510	4
β-strand	512-513	2	15
β-strand	518-519	2	15
α-helix	525-535	11
β-strand	540-542	3	16
α-helix	543-552	10
α-helix	560-562	3
β-strand	571-573	3	16
α-helix	574-579	6
α-helix	583	1
β-strand	588-589	2	17
β-strand	606-608	3	17
β-strand	611-614	4	17
α-helix	619-622	4
α-helix	629-637	9
α-helix	639-660	22
β-strand	663	1	18
α-helix	666-669	4
α-helix	675-695	21
α-helix	712-734	23
α-helix	742-748	7
α-helix	755-762	8
β-strand	766-767	2	19
β-strand	770	1	20
β-strand	773	1	20
β-strand	779	1	21
β-strand	782	1	21
α-helix	794-797	4
β-strand	799-800	2	19
α-helix	810-826	17
α-helix	830-843	14
β-strand	849-850	2	22
β-strand	856-857	2	22
β-strand	863-865	3	22
α-helix	868-870	3
β-strand	873	1	23
α-helix	875-877	3
β-strand	878-882	5	24
α-helix	884-886	3
α-helix	890-897	8
α-helix	916-919	4
α-helix	925-943	19
β-strand	953-957	5	24
α-helix	960-970	11
α-helix	983-994	12
α-helix	1005-1013	9
α-helix	1017-1024	8
α-helix	1028-1029	2
α-helix	1030-1034	5
α-helix	1039-1056	18
β-strand	1057	1	23
α-helix	1058-1059	2
α-helix	1064-1077	14
α-helix	1097-1105	9
β-strand	1116-1119	4	25
β-strand	1120	1	26
α-helix	1128-1138	11
β-strand	1141-1142	2	27
α-helix	1143-1145	3
β-strand	1147-1153	7	28
β-strand	1154	1	29
β-strand	1158	1	30
β-strand	1160	1	30
α-helix	1164-1166	3
α-helix	1168-1171	4
β-strand	1191	1	29
β-strand	1194-1197	4	28
α-helix	1200-1204	5
α-helix	1209-1220	12
β-strand	1225-1226	2	31
β-strand	1237-1238	2	28
β-strand	1240-1241	2	31
α-helix	1256-1268	13
β-strand	1272-1274	3	27
β-strand	1283-1287	5	25
β-strand	1290-1292	3	32
β-strand	1298-1300	3	32
β-strand	1303-1307	5	25
β-strand	1322	1	26
β-strand	1328-1329	2	25
α-helix	1332-1356	25
α-helix	1357-1359	3
α-helix	1366-1377	12
α-helix	1389-1391	3
α-helix	1396-1399	4
α-helix	1405-1413	9
β-strand	1418-1419	2	2
α-helix	1424-1430	7
β-strand	1437	1	33
β-strand	1441-1445	5	34
α-helix	1449-1452	4

Chain B: 51 helices, 69 β-strands

Element	Residues	Length	Sheet
α-helix	27-40	14
α-helix	45-52	8
α-helix	53-58	6
α-helix	59-63	5
β-strand	91	1	35
β-strand	95-100	6	36
β-strand	102-103	2	37
β-strand	109-110	2	37
α-helix	114-120	7
β-strand	123	1	38
β-strand	125-130	6	36
β-strand	133	1	35
β-strand	165-171	7	36
α-helix	180-182	3
α-helix	186-190	5
β-strand	203-204	2	39
β-strand	205	1	38
β-strand	209-211	3	39
α-helix	212-213	2
β-strand	214-218	5	40
β-strand	222-227	6	41
β-strand	234-242	9	41
β-strand	252-259	8	41
β-strand	270-272	3	41
β-strand	280-281	2	41
α-helix	282-287	6
α-helix	297-301	5
α-helix	308-321	14
α-helix	327-332	6
α-helix	347-354	8
α-helix	355-359	5
α-helix	371-389	19
α-helix	394-396	3
α-helix	401-403	3
β-strand	404-407	4	40
α-helix	409-425	17
α-helix	428-431	4
α-helix	454-462	9
β-strand	465	1	42
β-strand	477	1	42
β-strand	481-482	2	39
α-helix	488-495	8
β-strand	497	1	43
β-strand	498-499	2	40
β-strand	522	1	44
β-strand	538	1	43
β-strand	539	1	44
β-strand	540	1	45
β-strand	544-545	2	46
α-helix	552-555	4
β-strand	563-564	2	47
β-strand	578-582	5	47
β-strand	585-590	6	47
α-helix	594-606	13
β-strand	614-617	4	47
α-helix	619-621	3
β-strand	623-627	5	47
β-strand	633-639	7	46
α-helix	655-664	10
α-helix	681-686	6
β-strand	690-694	5	46
α-helix	695-698	4
β-strand	703-704	2	46
α-helix	728-730	3
β-strand	740-742	3	46
α-helix	745-747	3
β-strand	750	1	45
α-helix	753-755	3
α-helix	759-761	3
α-helix	764-773	10
α-helix	774-776	3
β-strand	779	1	48
α-helix	784-787	4
β-strand	793-796	4	48
β-strand	804-805	2	49
α-helix	807-811	5
α-helix	814-816	3
β-strand	820-827	8	50
β-strand	828	1	18
β-strand	838-841	4	50
α-helix	843-847	5
β-strand	853-861	9	48
β-strand	873	1	51
β-strand	910	1	52
β-strand	915-916	2	51
β-strand	935-936	2	51
α-helix	938-939	2
β-strand	940	1	52
α-helix	941	1
β-strand	948-955	8	48
β-strand	963-972	10	48
β-strand	979-981	3	50
β-strand	987-992	6	50
β-strand	1001	1	53
β-strand	1010-1011	2	50
α-helix	1014-1016	3
α-helix	1024-1038	15
α-helix	1041	1
β-strand	1042-1043	2	49
α-helix	1052-1062	11
β-strand	1070-1073	4	53
α-helix	1079	1
β-strand	1080-1085	6	53
β-strand	1086-1093	8	50
α-helix	1099-1101	3
β-strand	1104-1106	3	12
α-helix	1110	1
β-strand	1111	1	54
α-helix	1112	1
β-strand	1118	1	54
α-helix	1122-1124	3
β-strand	1129	1	11
α-helix	1132-1141	10
β-strand	1143	1	33
α-helix	1144-1151	8
β-strand	1159-1163	5	1
β-strand	1191-1195	5	1
α-helix	1198-1209	12
β-strand	1212	1	3
β-strand	1215-1217	3	2

Chain C: 7 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	55
β-strand	13	1	56
β-strand	18	1	56
β-strand	19-23	5	55
α-helix	27-39	13
β-strand	45-49	5	57
β-strand	53-54	2	58
α-helix	60-69	10
α-helix	75-79	5
β-strand	97-99	3	57
β-strand	102	1	58
β-strand	111-114	4	59
α-helix	115-117	3
β-strand	143-147	5	59
β-strand	153-154	2	58
β-strand	157-160	4	57
β-strand	176-179	4	55
α-helix	197-200	4
α-helix	205-209	5
β-strand	228-232	5	55
α-helix	242-263	22

Chain D: 10 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	21-23	3
β-strand	24	1	60
β-strand	28	1	60
α-helix	31-33	3
β-strand	36-39	4	61
β-strand	43-46	4	61
β-strand	50	1	62
α-helix	54-69	16
α-helix	119-121	3
α-helix	130-133	4
α-helix	139-150	12
α-helix	157-167	11
α-helix	175-182	8
α-helix	188-194	7
α-helix	204-215	12

Chain E: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	7-27	21
α-helix	32-35	4
α-helix	40-43	4
β-strand	47	1	63
β-strand	53	1	63
α-helix	55-57	3
β-strand	60-62	3	64
α-helix	68-71	4
β-strand	77-82	6	64
α-helix	91-103	13
β-strand	106-111	6	64
β-strand	131-134	4	64
α-helix	137-139	3
β-strand	152	1	65
α-helix	158-168	11
β-strand	177-178	2	65
α-helix	183-187	5
β-strand	195-202	8	65
β-strand	206-214	9	65

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	84	1	66
α-helix	85-86	2
α-helix	87-102	16
α-helix	117-126	10
β-strand	133-137	5	34
α-helix	138	1
β-strand	143-147	5	34
β-strand	152	1	66

Chain G: 3 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	2-5	4	62
β-strand	8-13	6	34
α-helix	15-17	3
α-helix	22-33	12
β-strand	38-39	2	62
β-strand	43-48	6	62
β-strand	55	1	34
β-strand	59-61	3	34
β-strand	68-73	6	34
β-strand	76-79	4	62
β-strand	86-95	10	67
β-strand	98-102	5	67
β-strand	108-111	4	67
β-strand	120-121	2	68
α-helix	122	1
β-strand	130-131	2	68
β-strand	136-137	2	68
β-strand	142-152	11	67
β-strand	157-162	6	67
β-strand	169	1	67

Chain H: 1 helix, 15 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	69
β-strand	24-30	7	69
β-strand	37-42	6	69
β-strand	54-60	7	69
α-helix	84-86	3
β-strand	98	1	70
β-strand	100-106	7	71
β-strand	112-114	3	71
β-strand	115	1	69
β-strand	116-117	2	71
β-strand	118	1	72
β-strand	121	1	72
β-strand	123-125	3	69
β-strand	127	1	71
β-strand	141	1	70
β-strand	143	1	69

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1733	SACCHAROMYCES CEREVISIAE	P04050 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1224	SACCHAROMYCES CEREVISIAE	P08518 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	318	SACCHAROMYCES CEREVISIAE	P16370 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB4	D	protein	221	SACCHAROMYCES CEREVISIAE	P20433 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	SACCHAROMYCES CEREVISIAE	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	SACCHAROMYCES CEREVISIAE	P20435
DNA-directed RNA polymerase II subunit RPB7	G	protein	171	SACCHAROMYCES CEREVISIAE	P34087
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	SACCHAROMYCES CEREVISIAE	P20436
DNA-directed RNA polymerase II subunit RPB9	I	protein	122	SACCHAROMYCES CEREVISIAE	P27999
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	SACCHAROMYCES CEREVISIAE	P22139
DNA-directed RNA polymerase II subunit RPB11	K	protein	120	SACCHAROMYCES CEREVISIAE	P38902
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	SACCHAROMYCES CEREVISIAE	P40422

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>2VUM_1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (chains A)
MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGS
IDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNE
LMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLK
LVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLP
VPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLE
LDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNA
DFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSP
KDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVR
FLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRR
LVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNI
RRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMT
LNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEH
TTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRA
AMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHML
KKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVP
GIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGG
LTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGA
FDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGS
NDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTS
PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS
PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR

Sequence of entity 2 (B), FASTA

>2VUM_2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (chains B)
MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQ
DIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLR
NLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCY
LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEI
RSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH
ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVS
QVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLS
LMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETL
RTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAK
LMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEEND
LDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIA
PGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDG
LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKK
LMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAA
KLLFQELMAMNITPRLYTDRSRDF

Sequence of entity 3 (C), FASTA

>2VUM_3 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (chains C)
MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLAD
EFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVI
VSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEY
DPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPV
DQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPY
SNASQMGNTGSGGYDNAW

Sequence of entity 4 (D), FASTA

>2VUM_4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 (chains D)
MNVSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQGEEEELIALNLSEARLVIK
EALVERRRAFKRSQKKHKKKHLKHENANDETTAVEDEDDDLDEDDVNADDDDFMHSETRE
KELESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAVIQLLKSTGLHPFEVAQL
GSLACDTADEAKTLIPSLNNKISDDELERILKELSNLETLY

Sequence of entity 5 (E), FASTA

>2VUM_5 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>2VUM_6 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>2VUM_7 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (chains G)
MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTGKFGYILCVLDYDNIDIQRGR
ILPTDGSAEFNVKYRAVVFKPFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLT
FNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAIGSIKEDYLGAI

Sequence of entity 8 (H), FASTA

>2VUM_8 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>2VUM_9 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 (chains I)
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQ
DIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQ
FS

Sequence of entity 10 (J), FASTA

>2VUM_10 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>2VUM_11 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (chains K)
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAA
YKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF

Sequence of entity 12 (L), FASTA

>2VUM_12 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8

Primary citation

Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation. Brueckner, F., Cramer, P. Nat Struct Mol Biol (2008) 15:811. DOI 10.1038/NSMB.1458 · PubMed

Other PDB entries of the same protein (UniProt P04050 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5VKO 1.8 Å, SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493
9SV6 1.96 Å, CryoEM structure of transcribing RNA polymerase II elongation complex with ATP and Elf1
5VKL 2.2 Å, SPT6 tSH2-RPB1 1476-1500 pS1493
9W8V 2.23 Å, Structure of post-translocation state of yeast Pol II complexed with a cisplatin-induced…
9QEB 2.26 Å, CryoEM structure of transcribing RNA polymerase II elongation complex
1TWF 2.3 Å, RNA polymerase II complexed with UTP at 2.3 A resolution
9RYB 2.33 Å, CryoEM structure of transcribing RNA polymerase II elongation complex in post-catalysis…
9KD8 2.46 Å, The structure of RNA polymerase II elongation complex paused at N-2 state by actinomycin…
6NPW 2.49 Å, SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide
9K7F 2.5 Å, RNA polymerase II elongation complex apo structure.
30ES 2.54 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…
30EP 2.55 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…

Browse structure collections

About this viewer

MolViewer shows 2VUM directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.