PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR. Determined by X-ray diffraction at 2.62 Å resolution. Released 18 Nov 2008.
Explore 2W2P in 3D Show helices and sheets RCSB PDB PDBe
2W2P contains 18 α-helices and 33 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 156-160 | 5 | |
| β-strand | 181-186 | 6 | 1 |
| β-strand | 200-206 | 7 | 1 |
| α-helix | 209-211 | 3 | |
| α-helix | 225-235 | 11 | |
| β-strand | 246-251 | 6 | 1 |
| β-strand | 258-260 | 3 | 2 |
| α-helix | 261-277 | 17 | |
| β-strand | 283-287 | 5 | 1 |
| β-strand | 289-290 | 2 | 2 |
| β-strand | 291-292 | 2 | 3 |
| α-helix | 295-306 | 12 | |
| β-strand | 310-314 | 5 | 1 |
| β-strand | 318 | 1 | 4 |
| β-strand | 321 | 1 | 5 |
| α-helix | 322-324 | 3 | |
| β-strand | 325-326 | 2 | 3 |
| β-strand | 334-339 | 6 | 1 |
| β-strand | 345 | 1 | 1 |
| β-strand | 347 | 1 | 4 |
| β-strand | 352 | 1 | 4 |
| β-strand | 355 | 1 | 5 |
| β-strand | 361-364 | 4 | 1 |
| β-strand | 368-372 | 5 | 6 |
| β-strand | 378-382 | 5 | 6 |
| α-helix | 385-402 | 18 | |
| α-helix | 408-418 | 11 | |
| β-strand | 420-421 | 2 | 1 |
| α-helix | 426-428 | 3 | |
| α-helix | 431-434 | 4 | |
| β-strand | 440-441 | 2 | 1 |
| α-helix | 444-446 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 292 | 1 | 7 |
| α-helix | 296-298 | 3 | |
| α-helix | 300-303 | 4 | |
| β-strand | 307-310 | 4 | 6 |
| β-strand | 313 | 1 | 7 |
| β-strand | 315-318 | 4 | 6 |
| β-strand | 325-326 | 2 | 8 |
| β-strand | 330-331 | 2 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 63-65 | 3 | 9 |
| α-helix | 70-72 | 3 | |
| β-strand | 73-82 | 10 | 9 |
| α-helix | 83 | 1 | |
| α-helix | 88-104 | 17 | |
| β-strand | 110-115 | 6 | 9 |
| β-strand | 121-125 | 5 | 9 |
| α-helix | 128-130 | 3 | |
| α-helix | 131-135 | 5 | |
| β-strand | 140-147 | 8 | 9 |
| β-strand | 148-151 | 4 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 | A | protein | 312 | HOMO SAPIENS | Q8NBP7 (AlphaFold model) |
| Low-density lipoprotein receptor | E | protein | 107 | HOMO SAPIENS | P01130 (AlphaFold model) |
| Proprotein convertase subtilisin/kexin type 9 | P | protein | 114 | HOMO SAPIENS | Q8NBP7 (AlphaFold model) |
>2W2P_1 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (chains A) SIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED GTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIR KSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPE VITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSACSTCFVSQSGTSQAAAHV AGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAA GTAAASHHHHHH
>2W2P_2 LOW-DENSITY LIPOPROTEIN RECEPTOR (chains E) MKHHHHHHPMSDYDIPTTENLYFQGAMGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL VAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACK
>2W2P_3 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (chains P) MKGSKGSKGSKPMSAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRL QAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 1 |
Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. Bottomley, M.J., Cirillo, A., Orsatti, L. et al. J Biol Chem (2009) 284:1313. DOI 10.1074/JBC.M808363200 · PubMed
Other PDB entries of the same protein (UniProt Q8NBP7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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