2X11: Complete EphA2 ectodomain

Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain. Determined by X-ray diffraction at 4.83 Å resolution. Released 16 Mar 2010.

Method
X-ray diffraction
Resolution
4.83 Å
Organism
Homo sapiens
Chains
2
Atoms
4,889
Mol. weight
80.26 kDa
Released
16 Mar 2010

Explore 2X11 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2X11 contains 21 α-helices and 62 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 54 β-strands

ElementResiduesLengthSheet
β-strand28-3361
α-helix34-363
β-strand44-4632
β-strand53-5971
β-strand62-7091
β-strand79-8242
α-helix83-853
β-strand86-8722
β-strand94-10291
β-strand10313
α-helix105-1073
β-strand11614
β-strand119-12682
α-helix136-1383
α-helix1391
β-strand140-14562
β-strand15113
α-helix154-1574
β-strand164-17071
β-strand177-18482
β-strand18714
β-strand188-199121
β-strand200-20125
α-helix202-2032
β-strand204-20636
β-strand209-21136
β-strand214-21525
α-helix216-2172
β-strand224-22747
β-strand229-23026
α-helix2311
β-strand234-23528
β-strand244-24747
β-strand25317
β-strand25717
β-strand261-26228
β-strand266-26949
β-strand272-27549
α-helix276-2772
β-strand280-281210
α-helix2901
β-strand291-292210
α-helix2931
β-strand297-298211
α-helix300-3012
α-helix3071
β-strand308-309211
α-helix3101
β-strand314112
α-helix324-3252
β-strand326112
β-strand332113
β-strand335-338414
β-strand344-348514
β-strand351113
β-strand361-369915
β-strand376-378315
α-helix379-3802
β-strand384-385214
β-strand392115
β-strand396-400514
β-strand407-415915
α-helix419-4213
β-strand427-431515
β-strand441-446616
β-strand453-457516
α-helix460-4634
β-strand468-475817
β-strand482-487617
β-strand491-493316
β-strand502-510917
β-strand517-518217
β-strand522-525417
Chain B: 2 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand35-39518
α-helix45-484
β-strand53-56419
β-strand61-65518
β-strand81-86619
α-helix88-936
β-strand100-106719
β-strand117-121518
β-strand138-146919
β-strand158-163619

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Ephrin type-a receptor 2Aprotein545Homo sapiensP29317 (AlphaFold model)
Ephrin-A5Bprotein177Homo sapiensP52803 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>2X11_1 EPHRIN TYPE-A RECEPTOR 2 (chains A)
MGILPSPGMPALLSLVSLLSVLLMGCVAKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNI
MNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKET
FNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGF
YLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPP
GGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTL
PSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGRE
DIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGV
SGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGD
SNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNGTKH
HHHHH
Sequence of entity 2 (B), FASTA
>2X11_2 EPHRIN-A5 (chains B)
MGILPSPGMPALLSLVSLLSVLLMGCVAAVADRYAVYWNSSNPRFQRGDYHIDVCINDYL
DVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKF
QLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKGTKHHHHHH

Primary citation

An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly. Seiradake, E., Harlos, K., Sutton, G. et al. Nat Struct Mol Biol (2010) 17:398. DOI 10.1038/NSMB.1782 · PubMed

Other PDB entries of the same protein (UniProt P29317 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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