2X19: Importin13 - RanGTP complex

Crystal structure of Importin13 - RanGTP complex. Determined by X-ray diffraction at 2.8 Å resolution. Released 16 Feb 2010.

Method

X-ray diffraction

Resolution

2.8 Å

Organisms

SACCHAROMYCES CEREVISIAE, HOMO SAPIENS

Chains

2

Atoms

8,440

Mol. weight

129.69 kDa

Ligands

GTP, MG

Released

16 Feb 2010

Explore 2X19 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2X19 contains 71 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 10 β-strands

Molecules and chains

>2X19_1 GTP-BINDING NUCLEAR PROTEIN GSP1/CNR1 (chains A)
GEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWD
TAGLEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVD
VKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFV

>2X19_2 IMPORTIN-13 (chains B)
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWH
FSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVL
TRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTS
RLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLT
LTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQF
RIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGN
PELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDH
EGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQ
QGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGF
FTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY

Ligands and cofactors

Primary citation

Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13. Bono, F., Cook, A.G., Grunwald, M. et al. Mol Cell (2010) 37:211. DOI 10.1016/J.MOLCEL.2010.01.007 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P32835 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 3M1I 2.0 Å, Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast…
• 3WYG 2.15 Å, Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex
• 5XOJ 2.2 Å, Crystal structure of Xpo1p-PKI-Nup42p-Gsp1p-GTP complex
• 3WYF 2.22 Å, Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex
• 9B3I 2.88 Å, Cryo-EM structure of yeast (Nap1)2-H2A-H2B-Kap114-RanGTP
• 8QYZ 3.0 Å, Crystal structure of hiNES2 in complex with Xpo1 and RanGTP
• 9D45 3.1 Å, Cryo-EM structure of yeast Exportin Msn5 bound to cargo Pho4 and RanGTP
• 9DZ6 3.1 Å, Cryo-EM structure of yeast Exportin Msn5 bound to RanGTP and Pho4 (not modeled) (State…
• 3ICQ 3.2 Å, Karyopherin nuclear state
• 9DXM 3.2 Å, Cryo-EM structure of yeast Exportin Msn5 bound to RanGTP and Pho4 (not modeled) (State…
• 9OGB 3.25 Å, Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to yeast…
• 8F1E 3.28 Å, Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B

Browse structure collections

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