2X7A: Bone marrow stromal antigen 2
Structural basis of HIV-1 tethering to membranes by the Bst2-tetherin ectodomain. Determined by X-ray diffraction at 2.77 Å resolution. Released 28 Apr 2010.
- Method
- X-ray diffraction
- Resolution
- 2.77 Å
- Organism
- HOMO SAPIENS
- Chains
- 11
- Atoms
- 4,673
- Mol. weight
- 76.36 kDa
- Ligands
- MG
- Released
- 28 Apr 2010
Explore 2X7A in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
2X7A contains 14 α-helices and 0 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-145 | 56 | |
Chain B: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-141 | 52 | |
Chain C: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-135 | 46 | |
Chain D: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 89-126 | 38 | |
| α-helix | 127-131 | 5 | |
| α-helix | 132-140 | 9 | |
Chain E: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 89-144 | 56 | |
Chains F and J: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-146 | 57 | |
Chain G: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 89-137 | 49 | |
Chain H: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-137 | 48 | |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Bone marrow stromal antigen 2 | A, B, C, D, E, F, G, H, I, J, K | protein | 61 | HOMO SAPIENS | Q10589 (AlphaFold model) |
Sequence of entity 1 (A, B, C, D, E, F, G, H, I, J, K), FASTA
>2X7A_1 BONE MARROW STROMAL ANTIGEN 2 (chains A, B, C, D, E, F, G, H, I, J, K)
QAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSV
R
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 1 |
Water and common crystallization additives (NA, CL, GOL) are not listed.
Primary citation
Structural Basis of HIV-1 Tethering to Membranes by the Bst-2/Tetherin Ectodomain. Hinz, A., Miguet, N., Natrajan, G. et al. Cell Host Microbe (2010) 7:314. DOI 10.1016/J.CHOM.2010.03.005 · PubMed
Other PDB entries of the same protein (UniProt Q10589 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7Q9A 2.1 Å, MHC Class I A02 Allele presenting LLLGIGILVL, in complex with Mel5 TCR
- 3MQ7 2.28 Å, Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317
- 3NWH 2.6 Å, Crystal structure of BST2/Tetherin
- 3MQ9 2.8 Å, Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317 Fused to MBP
- 3MQC 2.8 Å, Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21)
- 4P6Z 3.0 Å, Crystal structure of the human BST2 cytoplasmic domain and the HIV-1 Vpu cytoplasmic…
- 3MQB 3.2 Å, Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (C2)
- 2XG7 3.45 Å, Crystal Structure of BST2-Tetherin Ectodomain expressed in HEK293T cells
- 6CM9 3.73 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef closed trimer monomeric subunit
- 6DFF 3.9 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef monomer
- 6D83 4.27 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant…
- 6D84 6.72 Å, Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer
Browse structure collections
About this viewer
MolViewer shows 2X7A directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.