WDR5 in complex with an RBBP5 peptide recruited to novel site. Determined by X-ray diffraction at 2.4 Å resolution. Released 4 Aug 2010.
Explore 2XL2 in 3D Show helices and sheets RCSB PDB PDBe
2XL2 contains 4 α-helices and 56 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 36-41 | 6 | 1 |
| β-strand | 48-53 | 6 | 2 |
| β-strand | 59-64 | 6 | 2 |
| β-strand | 69-73 | 5 | 2 |
| β-strand | 79-83 | 5 | 2 |
| β-strand | 90-95 | 6 | 3 |
| β-strand | 101-106 | 6 | 3 |
| β-strand | 110-115 | 6 | 3 |
| β-strand | 120-126 | 7 | 3 |
| β-strand | 132-137 | 6 | 4 |
| β-strand | 143-148 | 6 | 4 |
| β-strand | 153-157 | 5 | 4 |
| β-strand | 163-167 | 5 | 4 |
| β-strand | 174-179 | 6 | 5 |
| β-strand | 185-190 | 6 | 5 |
| β-strand | 195-199 | 5 | 5 |
| β-strand | 204-209 | 6 | 5 |
| α-helix | 215-216 | 2 | |
| β-strand | 217-222 | 6 | 6 |
| β-strand | 228-233 | 6 | 6 |
| β-strand | 237-242 | 6 | 6 |
| β-strand | 247-252 | 6 | 6 |
| β-strand | 264-267 | 4 | 7 |
| β-strand | 273-276 | 4 | 7 |
| α-helix | 282 | 1 | |
| β-strand | 283-287 | 5 | 7 |
| β-strand | 293-297 | 5 | 7 |
| β-strand | 304-309 | 6 | 1 |
| β-strand | 315-320 | 6 | 1 |
| β-strand | 327-331 | 5 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Wd repeat-containing protein 5 | A, B | protein | 334 | MUS MUSCULUS | P61965 (AlphaFold model) |
| Retinoblastoma-binding protein 5 | C, D | protein | 14 | MUS MUSCULUS | Q8BX09 (AlphaFold model) |
>2XL2_1 WD REPEAT-CONTAINING PROTEIN 5 (chains A, B) MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH TDVVISTACHPTENIIASAALENDKTIKLWKSDC
>2XL2_2 RETINOBLASTOMA-BINDING PROTEIN 5 (chains C, D) YAAEDEEVDVTSVD
Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1. Odho, Z., Southall, S.M., Wilson, J.R. J Biol Chem (2010) 285:32967. DOI 10.1074/JBC.M110.159921 · PubMed
Other PDB entries of the same protein (UniProt P61965 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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