2XX5: Macrolactone Inhibitor

Name: PDB 2XX5: Macrolactone Inhibitor bound to HSP90 N-term
Published: 2011-11-16
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: chaperone

Macrolactone Inhibitor bound to HSP90 N-term. Determined by X-ray diffraction at 2.0 Å resolution. Released 16 Nov 2011.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: SACCHAROMYCES CEREVISIAE
Chains: 1
Atoms: 1,869
Mol. weight: 24.77 kDa
Ligands: 13N
Released: 16 Nov 2011

Explore 2XX5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2XX5 contains 14 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	2-3	2
β-strand	4-7	4	1
α-helix	8-9	2
α-helix	10-20	11
α-helix	27-29	3
α-helix	30-49	20
α-helix	53-58	6
β-strand	64-69	6	1
α-helix	70-72	3
β-strand	74-79	6	1
α-helix	86-92	7
α-helix	101-109	9
α-helix	114-120	7
α-helix	123-129	7
β-strand	131-139	9	1
β-strand	146-150	5	1
β-strand	155-160	6	1
α-helix	165-167	3
β-strand	170-177	8	1
α-helix	182-185	4
α-helix	187-197	11
β-strand	205-207	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ATP-dependent molecular chaperone HSP82	A	protein	214	SACCHAROMYCES CEREVISIAE	P02829 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2XX5_1 ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 (chains A)
MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVE

Ligands and cofactors

ID	Name	Formula	Copies
13N	(5E,10R)-N-benzyl-13-chloro-14,16-dihydroxy-1,11-dioxo-1,2,3,4,7,8,9,10,11,12-D…	C25 H27 Cl N2 O5	1

Water and common crystallization additives (GOL) are not listed.

Primary citation

Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Day, J.E., Sharp, S.Y., Rowlands, M.G. et al. ACS Chem Biol (2011) 6:1339. DOI 10.1021/CB200196E · PubMed

Other PDB entries of the same protein (UniProt P02829 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2IWX 1.5 Å, Analogues of radicicol bound to the ATP-binding site of Hsp90.
2BRC 1.6 Å, Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90.
2WER 1.6 Å, Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol
3C11 1.6 Å, Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA
1ZWH 1.65 Å, Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine
1AH6 1.8 Å, Structure of the tetragonal form of the N-terminal domain of the yeast HSP90 chaperone
1AMW 1.85 Å, ADP binding site in the HSP90 molecular chaperone
2XX2 1.85 Å, Macrolactone Inhibitor bound to HSP90 N-term
1ZW9 1.9 Å, Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsul…
2VW5 1.9 Å, Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of…
3C0E 1.9 Å, Yeast Hsp82 N-terminal domain: effects of mutants 98-99 KS-AA
2AKP 1.94 Å, Hsp90 Delta24-N210 mutant

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