2YGG: Complex of CaMBR and CaM

Complex of CaMBR and CaM. Determined by X-ray diffraction at 2.23 Å resolution. Released 28 Sept 2011.

Method: X-ray diffraction
Resolution: 2.23 Å
Organisms: HOMO SAPIENS, RATTUS NORVEGICUS
Chains: 2
Atoms: 1,885
Mol. weight: 26.36 kDa
Ligands: MRD, CA, TAM
Released: 28 Sept 2011

Explore 2YGG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YGG contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	625-651	27
α-helix	658-681	24

Chain B: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	27-28	2	1
α-helix	30-38	9
α-helix	46-56	11
β-strand	64-65	2	1
α-helix	66-93	28
β-strand	100-101	2	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-147	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sodium/hydrogen exchanger 1	A	protein	70	HOMO SAPIENS	P19634 (AlphaFold model)
Calmodulin	B	protein	150	RATTUS NORVEGICUS	P0DP29 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2YGG_1 SODIUM/HYDROGEN EXCHANGER 1 (chains A)
AFALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQK
INNYLTVPAH

Sequence of entity 2 (B), FASTA

>2YGG_2 CALMODULIN (chains B)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAKA

Ligands and cofactors

ID	Name	Formula	Copies
MRD	(4R)-2-methylpentane-2,4-diol	C6 H14 O2	1
CA	Calcium ion	Ca	4
TAM	Tris(hydroxyethyl)aminomethane	C7 H17 N O3	3

Water and common crystallization additives (MPD) are not listed.

Primary citation

Structure of Human Na+/H+ Exchanger Nhe1 Regulatory Region in Complex with Cam and Ca2+. Koester, S., Pavkov-Keller, T., Kuehlbrandt, W. et al. J Biol Chem (2011) 286:40954. DOI 10.1074/JBC.M111.286906 · PubMed

Other PDB entries of the same protein (UniProt P19634 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6NUC 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
6NUF 1.9 Å, Structure of Calcineurin in complex with NHE1 peptide
9NXE 2.09 Å, Crystal Structure of Calcineurin Clinical Variant E282K
6NUU 2.3 Å, Structure of Calcineurin mutant in complex with NHE1 peptide
2BEC 2.7 Å, Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into…
23XI 2.93 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Zoniporide in…
23XK 3.1 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in…
23XO 3.16 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Rimeporide in…
23XM 3.24 Å, Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Eniporide in an…
7DSW 3.3 Å, Structure of a human NHE1-CHP1 complex under pH 7.5
7DSV 3.4 Å, Structure of a human NHE1-CHP1 complex under pH 6.5
7DSX 3.5 Å, Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide

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