2YKA: RRM domain of mRNA export adaptor REF2-I

RRM domain of mRNA export adaptor REF2-I bound to HVS ORF57 peptide. Determined by solution NMR. Released 13 Jun 2012.

Method: Solution NMR
Organisms: MUS MUSCULUS, SAIMIRIINE HERPESVIRUS 2
Chains: 2
Atoms: 1,126
Mol. weight: 16.1 kDa
Released: 13 Jun 2012

Explore 2YKA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YKA contains 3 α-helices and 6 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	75-80	6	1
α-helix	88-96	9
β-strand	101-108	8	1
β-strand	114-122	9	1
α-helix	125-135	11
β-strand	138	1	2
β-strand	145	1	2
β-strand	146-150	5	1

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	108-118	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RNA and export factor-binding protein 2	A	protein	124	MUS MUSCULUS	Q9JJW6 (AlphaFold model)
52 kda immediate-early phosphoprotein	B	protein	23	SAIMIRIINE HERPESVIRUS 2	P13199 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2YKA_1 RNA AND EXPORT FACTOR-BINDING PROTEIN 2 (chains A)
MASMTGGQQMGRDPDKWQHDLFDSGCGGGEGVETGAKLLVSNLDFGVSDADIQELFAEFG
TLKKAAVDYDRSGRSLGTADVHFERRADALKAMKQYKGVPLDGRPMDIQLVASQIDLEHH
HHHH

Sequence of entity 2 (B), FASTA

>2YKA_2 52 KDA IMMEDIATE-EARLY PHOSPHOPROTEIN (chains B)
GPLGSSCKTSWADRVREAAAQRR

Primary citation

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri Orf57 to the Mammalian Export Adaptor Alyref. Tunnicliffe, R.B., Hautbergue, G.M., Wilson, S.A. et al. PLoS Pathog (2014) 10:3907. DOI 10.1371/JOURNAL.PPAT.1003907 · PubMed

Other PDB entries of the same protein (UniProt Q9JJW6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8SRR 3.22 Å, Cryo-EM structure of the CBC-ALYREF complex
2F3J The solution structure of the REF2-I mRNA export factor (residues 1-155).
2KT5 RRM domain of mRNA export adaptor REF2-I bound to HSV-1 ICP27 peptide

Browse structure collections

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