2YKT: I-BAR domain of IRSp53

Crystal structure of the I-BAR domain of IRSp53 (BAIAP2) in complex with an EHEC derived Tir peptide. Determined by X-ray diffraction at 2.11 Å resolution. Released 7 Sept 2011.

Method: X-ray diffraction
Resolution: 2.11 Å
Organisms: HOMO SAPIENS, ESCHERICHIA COLI O157\:H7
Chains: 2
Atoms: 1,991
Mol. weight: 30.24 kDa
Released: 7 Sept 2011

Explore 2YKT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YKT contains 8 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	5-19	15
α-helix	20-24	5
α-helix	25-64	40
α-helix	70-97	28
α-helix	98-102	5
α-helix	103-146	44
α-helix	159-228	70

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	453-455	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Brain-specific angiogenesis inhibitor 1-associated protein 2	A	protein	253	HOMO SAPIENS	Q9UQB8 (AlphaFold model)
Translocated intimin receptor protein	B	protein	13	ESCHERICHIA COLI O157\:H7	C6UYL8 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2YKT_1 BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 (chains A)
GSTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALV
KMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLS
AALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELEN
YVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIP
ERAVQLMQQVASN

Sequence of entity 2 (B), FASTA

>2YKT_2 TRANSLOCATED INTIMIN RECEPTOR PROTEIN (chains B)
GTVQNPYADVKTX

Primary citation

Structural Basis for Complex Formation between Human Irsp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. Coli. De Groot, J.C., Schluter, K., Carius, Y. et al. Structure (2011) 19:1294. DOI 10.1016/J.STR.2011.06.015 · PubMed

Other PDB entries of the same protein (UniProt Q9UQB8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6ZEG 1.09 Å, Structure of PP1-IRSp53 chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to…
6ZEI 1.39 Å, Structure of PP1-IRSp53 S455E chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)]…
3RNJ 1.5 Å, Crystal structure of the SH3 domain from IRSp53 (BAIAP2)
4JS0 1.9 Å, Complex of Cdc42 with the CRIB-PR domain of IRSp53
6BCR 1.99 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
1Y2O 2.2 Å, Structure of N-terminal domain IRSp53/BAIAP2
6BCY 2.3 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T360
6BD1 2.35 Å, Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at S366
1WDZ 2.63 Å, Crystal structure of RCB domain of IRSp53
6BQT 2.8 Å, Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360
6BD2 2.9 Å, Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366

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