2YXF: Beta-2-microglobulin

The high resolution crystal structure of beta2-microglobulin under physiological conditions. Determined by X-ray diffraction at 1.13 Å resolution. Released 30 Oct 2007.

Method: X-ray diffraction
Resolution: 1.13 Å
Organism: Homo sapiens
Chains: 1
Atoms: 919
Mol. weight: 11.88 kDa
Released: 30 Oct 2007

Explore 2YXF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YXF contains 3 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
α-helix	4-5	2
β-strand	6-12	7	2
α-helix	15-17	3
β-strand	22-30	9	2
β-strand	31	1	1
β-strand	36-41	6	3
β-strand	44-45	2	3
β-strand	51-56	6	2
β-strand	62-69	8	2
β-strand	78-83	6	3
β-strand	91-94	4	3
α-helix	95-96	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Beta-2-microglobulin	A	protein	100	Homo sapiens	P61769 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2YXF_1 Beta-2-microglobulin (chains A)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Primary citation

High-resolution Crystal Structure of {beta}2-Microglobulin Formed at pH 7.0. Iwata, K., Matsuura, T., Sakurai, K. et al. J Biochem (2007) 142:413-419. DOI 10.1093/jb/mvm148 · PubMed

Other PDB entries of the same protein (UniProt P61769 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4E0K 0.97 Å, Crystal Structure of the amyloid-fibril forming peptide KDWSFY derived from human Beta 2…
1K5N 1.09 Å, HLA-B*2709 bound to nona-peptide M9
3MRE 1.1 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288…
8E2Z 1.13 Å, Structures of HLA-B8E76C loaded with long peptides reveal novel features at the…
7NMR 1.15 Å, Crystal structure of beta-2-microglobulin D76S mutant
8ROP 1.15 Å, Crystal structure of HLA B*18:01 in complex with QEIRTFSF, an 8-mer epitope from…
7R7W 1.17 Å, Crystal structure of HLA-B*5301 complex with an HIV-1 Gag-derived epitope QW9 S3T variant
4U1M 1.18 Å, HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential…
3CZF 1.2 Å, Crystal structure of HLA-B*2709 complexed with the glucagon receptor (GR) peptide…
6Y26 1.2 Å, Crystal structure of HLA-B2705 complexed with the nona-peptide mA
7NMC 1.2 Å, Crystal structure of beta-2-microglobulin D76E mutant
7NMO 1.2 Å, Crystal structure of beta-2-microglobulin D76A mutant

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