32QM: Human TRIM21 PRYSPRY domain

Human TRIM21 PRYSPRY domain in complex with compound 5 (Z31). Determined by X-ray diffraction at 1.5 Å resolution. Released 29 Jul 2026.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,564
Mol. weight: 21.08 kDa
Ligands: A1KEE
Released: 29 Jul 2026

Explore 32QM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

32QM contains 5 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	291	1	1
α-helix	293-295	3
β-strand	300-302	3	2
β-strand	308-311	4	2
β-strand	331-332	2	3
β-strand	333	1	1
β-strand	337	1	3
β-strand	341-347	7	2
β-strand	354-360	7	3
α-helix	373-375	3
β-strand	377-383	7	3
β-strand	387-390	4	3
β-strand	396-398	3	3
β-strand	406-412	7	2
β-strand	417-422	6	2
α-helix	423-425	3
β-strand	428-433	6	2
β-strand	442-447	6	3
β-strand	452	1	4
β-strand	455	1	4
α-helix	458-459	2
β-strand	460-462	3	2
α-helix	463-464	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase TRIM21	A	protein	181	Homo sapiens	P19474 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>32QM_1 E3 ubiquitin-protein ligase TRIM21 (chains A)
SMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYW
EVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
L

Ligands and cofactors

ID	Name	Formula	Copies
A1KEE	~{N}-[(1~{R})-1-cyclohexylethyl]-4-(4-fluoranyl-2-methylsulfanyl-phenyl)-~{N}-m…	C24 H30 F N O3 S2	1

Water and common crystallization additives (EDO) are not listed.

Primary citation

Human TRIM21 PRYSPRY domain in complex with compound 5 (Z31). Kim, Y., Schallmayer, L., Knapp, S. et al. To be published.

Other PDB entries of the same protein (UniProt P19474 (AlphaFold model), which also has an AlphaFold model), best resolution first:

32QO 1.3 Å, Human TRIM21 PRYSPRY domain in complex with compound 28 (Z38)
9PLM 1.32 Å, TRIM21-NUP98 Molecular Glue Complex (MAN-021)
32QL 1.4 Å, Human TRIM21 PRYSPRY domain in complex with HGC652
9QBA 1.45 Å, Human TRIM21 PRYSPRY domain in complex with AL236
9II5 1.49 Å, Crystal structure of human TRIM21 PRYSPRY in complex with compound 1
8Y58 1.6 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine.
9PLL 1.6 Å, TRIM21-NUP98 Molecular Glue Complex (MAN-056)
8Y5B 1.74 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (R)-hydroxyl-acepromazine.
32QN 1.8 Å, Human TRIM21 PRYSPRY domain in complex with compound 29 (Z37)
8Y59 1.89 Å, Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (S)-hydroxyl-acepromazine.
5OLM 1.95 Å, TRIM21
9M3N 2.08 Å, Crystal structure of human TRIM21 PRYSPRY in complex with T-02

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