Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA. Determined by X-ray diffraction at 2.1 Å resolution. Released 19 Feb 2008.
Explore 3C0Z in 3D Show helices and sheets RCSB PDB PDBe
3C0Z contains 66 α-helices and 58 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 520-523 | 4 | 1 |
| α-helix | 526-530 | 5 | |
| α-helix | 538-540 | 3 | |
| α-helix | 546-557 | 12 | |
| α-helix | 561-563 | 3 | |
| β-strand | 565-567 | 3 | 1 |
| α-helix | 571-573 | 3 | |
| α-helix | 574-577 | 4 | |
| α-helix | 583-590 | 8 | |
| α-helix | 601-609 | 9 | |
| β-strand | 615 | 1 | 2 |
| β-strand | 621 | 1 | 2 |
| β-strand | 622 | 1 | 3 |
| β-strand | 628 | 1 | 3 |
| α-helix | 634-653 | 20 | |
| β-strand | 659-662 | 4 | 1 |
| β-strand | 672 | 1 | 4 |
| β-strand | 675 | 1 | 4 |
| β-strand | 677 | 1 | 5 |
| β-strand | 680 | 1 | 5 |
| α-helix | 684-695 | 12 | |
| β-strand | 701-705 | 5 | 1 |
| α-helix | 712-718 | 7 | |
| β-strand | 724-731 | 8 | 1 |
| α-helix | 750-752 | 3 | |
| β-strand | 756-761 | 6 | 1 |
| β-strand | 770 | 1 | 6 |
| α-helix | 771-777 | 7 | |
| α-helix | 778-782 | 5 | |
| α-helix | 783-789 | 7 | |
| β-strand | 793-798 | 6 | 1 |
| β-strand | 803 | 1 | 7 |
| α-helix | 808-810 | 3 | |
| β-strand | 814 | 1 | 6 |
| β-strand | 815 | 1 | 7 |
| α-helix | 817-827 | 11 | |
| α-helix | 831-833 | 3 | |
| β-strand | 835-839 | 5 | 1 |
| α-helix | 845-860 | 16 | |
| α-helix | 866-868 | 3 | |
| α-helix | 870-872 | 3 | |
| α-helix | 875-877 | 3 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-898 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 520-523 | 4 | 8 |
| α-helix | 526-530 | 5 | |
| α-helix | 546-557 | 12 | |
| α-helix | 561-563 | 3 | |
| β-strand | 565-567 | 3 | 8 |
| α-helix | 571-573 | 3 | |
| α-helix | 574-578 | 5 | |
| α-helix | 583-590 | 8 | |
| β-strand | 615 | 1 | 9 |
| β-strand | 621 | 1 | 9 |
| β-strand | 622 | 1 | 10 |
| β-strand | 628 | 1 | 10 |
| α-helix | 634-653 | 20 | |
| β-strand | 659-662 | 4 | 8 |
| β-strand | 672 | 1 | 11 |
| β-strand | 675 | 1 | 11 |
| β-strand | 677 | 1 | 12 |
| β-strand | 680 | 1 | 12 |
| α-helix | 684-694 | 11 | |
| β-strand | 701-705 | 5 | 8 |
| α-helix | 712-718 | 7 | |
| β-strand | 724-731 | 8 | 8 |
| α-helix | 750-752 | 3 | |
| β-strand | 756-761 | 6 | 8 |
| α-helix | 768-769 | 2 | |
| β-strand | 770 | 1 | 13 |
| α-helix | 771-777 | 7 | |
| α-helix | 778-782 | 5 | |
| α-helix | 783-789 | 7 | |
| β-strand | 793-798 | 6 | 8 |
| β-strand | 803 | 1 | 14 |
| β-strand | 814 | 1 | 13 |
| β-strand | 815 | 1 | 14 |
| α-helix | 817-827 | 11 | |
| α-helix | 831-833 | 3 | |
| β-strand | 835-839 | 5 | 8 |
| α-helix | 845-859 | 15 | |
| α-helix | 875-877 | 3 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-898 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 520-523 | 4 | 15 |
| α-helix | 526-530 | 5 | |
| α-helix | 546-557 | 12 | |
| α-helix | 561-563 | 3 | |
| β-strand | 565-567 | 3 | 15 |
| α-helix | 571-573 | 3 | |
| α-helix | 574-578 | 5 | |
| α-helix | 583-590 | 8 | |
| β-strand | 622 | 1 | 16 |
| β-strand | 628 | 1 | 16 |
| α-helix | 634-653 | 20 | |
| β-strand | 659-662 | 4 | 15 |
| β-strand | 672 | 1 | 17 |
| β-strand | 675 | 1 | 17 |
| β-strand | 677 | 1 | 18 |
| β-strand | 680 | 1 | 18 |
| α-helix | 684-694 | 11 | |
| β-strand | 701-705 | 5 | 15 |
| α-helix | 712-718 | 7 | |
| β-strand | 724-731 | 8 | 15 |
| α-helix | 733-735 | 3 | |
| α-helix | 750-752 | 3 | |
| β-strand | 756-761 | 6 | 15 |
| β-strand | 770 | 1 | 19 |
| α-helix | 771-777 | 7 | |
| α-helix | 778-782 | 5 | |
| α-helix | 783-789 | 7 | |
| β-strand | 793-798 | 6 | 15 |
| β-strand | 803 | 1 | 20 |
| β-strand | 814 | 1 | 19 |
| β-strand | 815 | 1 | 20 |
| α-helix | 817-828 | 12 | |
| α-helix | 831-833 | 3 | |
| β-strand | 835-839 | 5 | 15 |
| α-helix | 845-859 | 15 | |
| α-helix | 866-868 | 3 | |
| α-helix | 870-872 | 3 | |
| α-helix | 875-877 | 3 | |
| α-helix | 878-891 | 14 | |
| α-helix | 896-898 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Histone deacetylase 7a | A, B, C | protein | 423 | Homo sapiens | Q8WUI4 (AlphaFold model) |
>3C0Z_1 Histone deacetylase 7a (chains A, B, C) GSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSR HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQ DPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRI VVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALE GGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR LAS
Water and common crystallization additives (K) are not listed.
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. Schuetz, A., Min, J., Allali-Hassani, A. et al. J Biol Chem (2008) 283:11355-11363. DOI 10.1074/jbc.M707362200 · PubMed
Other PDB entries of the same protein (UniProt Q8WUI4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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