3CBZ: The Dvl2 PDZ Domain

The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide. Determined by X-ray diffraction at 1.38 Å resolution. Released 3 Mar 2009.

Method: X-ray diffraction
Resolution: 1.38 Å
Organism: Homo sapiens
Chains: 1
Atoms: 901
Mol. weight: 11.64 kDa
Ligands: PO4
Released: 3 Mar 2009

Explore 3CBZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3CBZ contains 4 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	265-270	6	1
α-helix	272-275	4
β-strand	280-285	6	1
β-strand	293-299	7	1
α-helix	304-308	5
α-helix	315	1
β-strand	316-320	5	1
β-strand	323-324	2	1
α-helix	330-341	12
β-strand	347-352	6	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Dishevelled-2	A	protein	108	Homo sapiens	O14641 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3CBZ_1 Dishevelled-2 (chains A)
GSHMNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQ
VNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKSGGGSGNEVWIDGP

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	1

Water and common crystallization additives (EDO) are not listed.

Primary citation

Inhibition of Wnt signaling by Dishevelled PDZ peptides. Zhang, Y., Appleton, B.A., Wiesmann, C. et al. Nat Chem Biol (2009) 5:217-219. DOI 10.1038/nchembio.152 · PubMed

Other PDB entries of the same protein (UniProt O14641 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3CBY 1.5 Å, The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide
2REY 1.55 Å, Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)
6IW3 1.64 Å, High resolution structure of Dvl2-DIX Y27W/C80S mutant
3CBX 1.7 Å, The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide
3CC0 1.75 Å, The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide
8WWR 1.75 Å, Crystal structure of apo human dishevelled 2 (Dvl2) PDZ domain
5SUZ 1.84 Å, Domain-swapped dimer of human Dishevelled2 DEP domain: C-centered monoclinic crystal…
5SUY 1.88 Å, Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form…
35UG 1.95 Å, Human DVL2 PDZ domain in complex with Vangl2
5LNP 1.99 Å, Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form…
4WIP 2.69 Å, DIX domain of human Dvl2
8YR7 3.0 Å, Crystal structure of human dishevelled 2 (Dvl2) PDZ domain fused with WGEF internal…

Browse structure collections

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