3CD4: T cell surface glycoprotein CD4

Refinement and analysis of the first two domains of human CD4. Determined by X-ray diffraction at 2.2 Å resolution. Released 31 Oct 1993.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,419
Mol. weight: 20.2 kDa
Released: 31 Oct 1993

Explore 3CD4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3CD4 contains 4 α-helices and 24 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	12-14	3	2
β-strand	17	1	3
β-strand	26-30	5	1
β-strand	35-40	6	1
β-strand	43-45	3	1
β-strand	55-56	2	2
α-helix	59-64	6
β-strand	66	1	3
β-strand	69-71	3	2
α-helix	76-78	3
β-strand	80-86	7	1
β-strand	89-98	10	1
β-strand	99-102	4	4
β-strand	108-109	2	5
α-helix	112-113	2
β-strand	114-119	6	4
β-strand	127-129	3	6
β-strand	131	1	7
β-strand	139-140	2	6
β-strand	143-146	4	4
α-helix	151-153	3
β-strand	155-156	2	8
β-strand	158	1	7
β-strand	159-163	5	6
β-strand	166-170	5	6
β-strand	173-174	2	8
β-strand	176-177	2	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T cell surface glycoprotein CD4	A	protein	182	Homo sapiens	P01730 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3CD4_1 T CELL SURFACE GLYCOPROTEIN CD4 (chains A)
KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRS
LWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLES
PPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQ
KA

Primary citation

Refinement and analysis of the structure of the first two domains of human CD4. Garrett, T.P.J., Wang, J., Yan, Y. et al. J Mol Biol (1993) 234:763-778. DOI 10.1006/jmbi.1993.1625 · PubMed

Other PDB entries of the same protein (UniProt P01730 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8W90 1.81 Å, crystal structure of CD4-D1D2 with Nb457
4H8W 1.85 Å, Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with…
2NY1 1.99 Å, HIV-1 gp120 Envelope Glycoprotein (I109C, T257S, S334A, S375W, Q428C) Complexed with CD4…
1CDY 2.0 Å, Structure of T-cell surface glycoprotein CD4 mutant with gly 47 replaced by ser
2NXY 2.0 Å, HIV-1 gp120 Envelope Glycoprotein(S334A) Complexed with CD4 and Antibody 17b
2NY2 2.0 Å, HIV-1 gp120 Envelope Glycoprotein (T123C, T257S, S334A, S375W, G431C) Complexed with CD4…
2NY3 2.0 Å, HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4…
2NY4 2.0 Å, HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E268C, S334A, S375W) Complexed with CD4…
2NXZ 2.04 Å, HIV-1 gp120 Envelope Glycoprotein (T257S, S334A, S375W) Complexed with CD4 and Antibody…
3S5L 2.1 Å, Crystal structure of CD4 mutant bound to HLA-DR1
3O2D 2.19 Å, Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral…
1G9M 2.2 Å, HIV-1 HXBC2 GP120 envelope glycoprotein complexed with CD4 and induced neutralizing…

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