3CHN: Human secretory IgA1

Solution structure of human secretory IgA1. Determined by solution scattering. Released 30 Dec 2008.

Method

Solution scattering

Organism

Homo sapiens

Chains

10

Atoms

3,447

Mol. weight

373.35 kDa

Released

30 Dec 2008

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Molecules and chains

>3CHN_1 Immunoglobulin kappa light chain (chains L, M, N, O)
ELVMTQSPSSLSASVGDRVNIACRASQGISSALAWYQQKPGKAPRLLIYDASNLESGVPS
RFSGSGSGTDFTLTISSLQPEDFAIYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

>3CHN_2 Ig alpha-1 chain C region (chains A, B, C, D)
QVKLLEQSGAEVKKPGASVKVSCKASGYSFTSYGLHWVRQAPGQRLEWMGWISAGTGNTK
YSQKFRGRVTFTRDTSATTAYMGLSSLRPEDTAVYYCARDPYGGGKSEFDYWGQGTLVTV
SSASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQD
ASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTP
SPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERD
LCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSE
ELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSIL
RVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY

>3CHN_3 Secretory component (chains J)
PRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGR
LSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKII

>3CHN_4 Secretory component (chains S)
KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKY
AGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTK
VYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGT
GQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCA
LGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKE
DAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKES
KSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGF
YWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKW
NNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAV
YVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPR

Primary citation

Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Bonner, A., Almogren, A., Furtado, P.B. et al. Mucosal Immunol (2009) 2:74-84. DOI 10.1038/mi.2008.68 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P01876 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9R2E 2.54 Å, Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1
• 9OFR 2.65 Å, Crystal structure of the human IGA1 fc fragment-fc-alpha receptor (CD89) complex
• 6UE7 2.9 Å, Structure of dimeric sIgA complex
• 1OW0 3.1 Å, Crystal structure of human FcaRI bound to IgA1-Fc
• 8SKV 3.1 Å, Structure of human SIgA1 in complex with Streptococcus pyogenes protein M4 (Arp4)
• 6LX3 3.15 Å, Cryo-EM structure of human secretory immunoglobulin A
• 2QEJ 3.2 Å, Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human…
• 8SKU 3.2 Å, Structure of human SIgA1 in complex with human CD89 (FcaR1)
• 6LXW 3.27 Å, Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal…
• 9MBZ 3.3 Å, Cryo-EM structure of human FcRL4 bound to IgA-Fc/J
• 7UVL 3.56 Å, IgA1 Protease with IgA1 substrate
• 6XJA 4.0 Å, Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate

Browse structure collections

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