3CJJ: Human rage ligand-binding domain

Crystal structure of human rage ligand-binding domain. Determined by X-ray diffraction at 1.85 Å resolution. Released 24 Mar 2009.

Method: X-ray diffraction
Resolution: 1.85 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,938
Mol. weight: 24.33 kDa
Ligands: ZN
Released: 24 Mar 2009

Explore 3CJJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3CJJ contains 7 α-helices and 21 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	23	1
β-strand	24-29	6	1
β-strand	34-36	3	2
β-strand	49-55	7	1
β-strand	62-64	3	1
β-strand	77-78	2	2
β-strand	84-86	3	2
α-helix	91-93	3
β-strand	95-102	8	1
β-strand	108-118	11	1
β-strand	119	1	3
α-helix	122-124	3
β-strand	125-127	3	4
β-strand	132-134	3	5
β-strand	139-149	11	4
β-strand	150	1	3
β-strand	154-159	6	6
β-strand	162-163	2	6
α-helix	164-165	2
β-strand	171-179	9	4
β-strand	186-194	9	4
α-helix	196-197	2
β-strand	206-211	6	6
β-strand	220-221	2	6
α-helix	222-224	3
β-strand	225	1	6
α-helix	227	1
β-strand	228-230	3	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Advanced glycosylation end product-specific receptor	A	protein	219	Homo sapiens	Q15109 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3CJJ_1 Advanced glycosylation end product-specific receptor (chains A)
MAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPN
GSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKV
GTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGD
PRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Water and common crystallization additives (ACT) are not listed.

Primary citation

Structural basis for ligand recognition and activation of RAGE. Koch, M., Chitayat, S., Dattilo, B.M. et al. Structure (2010) 18:1342-1352. DOI 10.1016/j.str.2010.05.017 · PubMed

Other PDB entries of the same protein (UniProt Q15109 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5D7F 1.3 Å, X-ray structure of Ca(2+)-S100B with human RAGE-derived W72 peptide
3O3U 1.5 Å, Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)
6XQ1 1.51 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with…
6XQ3 1.71 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with…
6XQ5 1.8 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 1
6XQ7 1.8 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 5
6XQ8 1.82 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 11
6XQ6 1.9 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 11
7LML 2.15 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with…
4P2Y 2.3 Å, Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse…
6XQ9 2.3 Å, Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 13
9S2X 2.35 Å, Crystal structure of the human RAGE ectodomain in complex with murine S100A6 mutant Y84C

Browse structure collections

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