3CQZ: 10 subunit RNA polymerase II

Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin. Determined by X-ray diffraction at 2.8 Å resolution. Released 22 Jul 2008.

Method: X-ray diffraction
Resolution: 2.8 Å
Organisms: SACCHAROMYCES CEREVISIAE, AMANITA PHALLOIDES
Chains: 11
Atoms: 27,340
Mol. weight: 471.09 kDa
Ligands: ZN
Released: 22 Jul 2008

Explore 3CQZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3CQZ contains 172 α-helices and 196 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 73 helices, 69 β-strands

Element	Residues	Length	Sheet
α-helix	10	1
β-strand	11	1	1
β-strand	16-21	6	2
α-helix	24-30	7
β-strand	34	1	3
β-strand	82-91	10	3
α-helix	93-95	3
α-helix	96-103	8
β-strand	106	1	4
β-strand	113	1	4
α-helix	120-127	8
α-helix	131-142	12
β-strand	147	1	5
β-strand	151-152	2	6
β-strand	162-163	2	6
α-helix	169	1
β-strand	170	1	5
α-helix	171-172	2
β-strand	173-177	5	7
β-strand	180-185	6	7
β-strand	198-202	5	7
α-helix	204-213	10
α-helix	216-221	6
β-strand	225	1	8
β-strand	229	1	8
α-helix	231-234	4
β-strand	235-241	7	3
α-helix	242-243	2
α-helix	266-280	15
α-helix	286-301	16
β-strand	348-355	8	9
β-strand	363-367	5	9
α-helix	368-371	4
β-strand	375-379	5	10
α-helix	385-394	10
β-strand	402-406	5	10
β-strand	412-414	3	10
α-helix	426-427	2
β-strand	431-435	5	10
α-helix	436	1
β-strand	441-445	5	9
β-strand	455-463	9	9
β-strand	468-470	3	9
α-helix	472-474	3
α-helix	475-478	4
β-strand	486-490	5	9
α-helix	495-500	6
α-helix	501-505	5
β-strand	506	1	9
α-helix	507-510	4
β-strand	512-513	2	11
β-strand	518-519	2	11
α-helix	525-535	11
β-strand	540-542	3	12
α-helix	543-552	10
α-helix	561-563	3
β-strand	565-567	3	12
β-strand	571-573	3	12
α-helix	574-578	5
α-helix	579-581	3
α-helix	583	1
β-strand	588-590	3	13
β-strand	605-608	4	13
β-strand	611-614	4	13
α-helix	619-622	4
α-helix	629-637	9
α-helix	639-660	22
β-strand	662	1	14
α-helix	666-669	4
α-helix	675-699	25
α-helix	710-736	27
α-helix	742-749	8
α-helix	755-762	8
β-strand	766-767	2	15
β-strand	770	1	16
β-strand	773	1	16
α-helix	775-776	2
β-strand	779	1	17
β-strand	782	1	17
α-helix	788	1
β-strand	799-800	2	15
α-helix	810-827	18
α-helix	835-845	11
β-strand	849-850	2	18
β-strand	856-857	2	18
β-strand	863-865	3	18
α-helix	868-870	3
β-strand	873	1	19
α-helix	875-877	3
β-strand	878-882	5	20
α-helix	884-886	3
α-helix	890-897	8
α-helix	910-912	3
β-strand	913	1	21
α-helix	923-946	24
β-strand	953-957	5	20
α-helix	960-970	11
β-strand	979	1	21
α-helix	983-994	12
α-helix	1005-1014	10
α-helix	1016-1025	10
α-helix	1028-1029	2
α-helix	1030-1035	6
α-helix	1039-1054	16
β-strand	1057	1	19
α-helix	1058-1059	2
α-helix	1064-1073	10
α-helix	1075-1077	3
α-helix	1099-1106	8
β-strand	1115	1	22
β-strand	1116-1118	3	23
β-strand	1120	1	24
α-helix	1128-1138	11
β-strand	1141-1142	2	25
α-helix	1143-1146	4
β-strand	1147-1154	8	26
α-helix	1164-1166	3
α-helix	1167-1170	4
β-strand	1191-1197	7	26
α-helix	1199-1203	5
α-helix	1209-1217	9
α-helix	1221-1223	3
β-strand	1225-1228	4	26
β-strand	1236-1241	6	26
α-helix	1261-1268	8
β-strand	1272-1274	3	25
β-strand	1281-1287	7	23
β-strand	1290-1292	3	27
β-strand	1298-1300	3	27
β-strand	1303-1309	7	23
β-strand	1310	1	22
α-helix	1313-1316	4
β-strand	1322	1	24
β-strand	1328-1329	2	23
α-helix	1332-1338	7
α-helix	1341-1358	18
α-helix	1365-1374	10
α-helix	1406-1415	10
β-strand	1418-1419	2	2
α-helix	1424-1429	6
α-helix	1437-1439	3
β-strand	1441-1445	5	28

Chain B: 55 helices, 64 β-strands

Element	Residues	Length	Sheet
α-helix	24-26	3
α-helix	30-41	12
α-helix	45-53	9
α-helix	54-58	5
α-helix	59-64	6
β-strand	91-97	7	29
α-helix	98-100	3
β-strand	101-102	2	30
β-strand	110-111	2	30
α-helix	114-119	6
β-strand	125-133	9	29
β-strand	166-171	6	29
α-helix	172-173	2
α-helix	180-183	4
α-helix	186-191	6
β-strand	203-205	3	31
β-strand	208-212	5	31
α-helix	213	1
β-strand	214-218	5	32
α-helix	219	1
β-strand	224-227	4	33
β-strand	234-242	9	33
β-strand	252-259	8	33
β-strand	268-272	5	33
β-strand	280-281	2	33
α-helix	282-288	7
α-helix	294-301	8
α-helix	308-312	5
α-helix	315-320	6
α-helix	327-336	10
α-helix	345-354	10
α-helix	355-359	5
α-helix	371-389	19
α-helix	394-396	3
α-helix	401-403	3
β-strand	404-407	4	32
α-helix	409-425	17
α-helix	427-429	3
α-helix	451-463	13
β-strand	480-482	3	31
α-helix	483-484	2
α-helix	488-495	8
β-strand	497-499	3	32
α-helix	516-518	3
β-strand	522	1	34
β-strand	536-538	3	32
β-strand	539	1	34
β-strand	544-545	2	35
α-helix	552-560	9
β-strand	563-565	3	36
α-helix	571-573	3
α-helix	577	1
β-strand	578-582	5	36
β-strand	585-590	6	36
α-helix	593-604	12
β-strand	614-618	5	36
β-strand	623-627	5	36
β-strand	633-639	7	35
β-strand	640-641	2	37
β-strand	650-651	2	37
α-helix	655-666	12
α-helix	681-686	6
β-strand	690-694	5	35
α-helix	697-700	4
β-strand	703-704	2	35
α-helix	707-710	4
α-helix	728-729	2
β-strand	740-741	2	35
α-helix	745-748	4
α-helix	753-755	3
α-helix	759-761	3
α-helix	764-773	10
α-helix	774-776	3
β-strand	777	1	38
β-strand	779	1	39
α-helix	785-787	3
β-strand	792-796	5	39
β-strand	800	1	40
β-strand	804-805	2	41
α-helix	809-812	4
β-strand	821-827	7	42
β-strand	829	1	14
β-strand	838-842	5	42
α-helix	843-847	5
β-strand	853-862	10	39
β-strand	873-874	2	43
β-strand	898	1	44
β-strand	904-906	3	39
β-strand	910-912	3	44
β-strand	914-916	3	43
β-strand	935-936	2	43
β-strand	939-940	2	44
β-strand	946-956	11	39
β-strand	962-972	11	39
β-strand	979-981	3	42
β-strand	987-994	8	42
α-helix	996-998	3
β-strand	1001	1	45
β-strand	1010-1012	3	42
α-helix	1014-1016	3
α-helix	1023-1038	16
β-strand	1042-1043	2	41
α-helix	1052-1061	10
β-strand	1069-1070	2	42
β-strand	1073	1	45
α-helix	1079	1
β-strand	1080	1	45
α-helix	1081	1
β-strand	1085-1094	10	42
β-strand	1095	1	38
α-helix	1096	1
α-helix	1132-1140	9
α-helix	1144-1151	8
β-strand	1158-1163	6	1
β-strand	1172	1	46
β-strand	1182	1	46
β-strand	1192-1197	6	1
α-helix	1199-1210	12
β-strand	1213-1218	6	2

Chain C: 15 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	47
β-strand	12-13	2	47
β-strand	17-23	7	47
α-helix	27-39	13
β-strand	43-54	12	48
α-helix	60-69	10
β-strand	72	1	49
α-helix	77-79	3
α-helix	81-82	2
α-helix	83-85	3
β-strand	96-104	9	48
α-helix	110	1
β-strand	111-114	4	50
α-helix	115-117	3
β-strand	119-120	2	48
α-helix	131	1
β-strand	132	1	49
α-helix	133	1
β-strand	143-147	5	50
β-strand	152-162	11	48
α-helix	168-170	3
β-strand	173-177	5	47
β-strand	180	1	47
α-helix	197-200	4
α-helix	202-204	3
α-helix	205-207	3
α-helix	211-214	4
β-strand	227-234	8	47
α-helix	240-264	25

Chain E: 14 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
β-strand	28	1	51
α-helix	32-35	4
α-helix	39-45	7
α-helix	55-58	4
β-strand	60-62	3	52
β-strand	64	1	51
α-helix	68-71	4
β-strand	78-82	5	52
β-strand	87-88	2	53
α-helix	91-101	11
β-strand	107-112	6	52
β-strand	115-116	2	53
β-strand	131-136	6	52
α-helix	137-140	4
α-helix	144-146	3
β-strand	152-155	4	54
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	54
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-202	8	54
β-strand	206-214	9	54

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	84	1	55
α-helix	85-86	2
α-helix	87-101	15
α-helix	117-126	10
β-strand	132-137	6	28
α-helix	138	1
β-strand	143-147	5	28
β-strand	152	1	55

Chain H: 0 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	6-11	6	12
β-strand	12-16	5	56
β-strand	23-29	7	56
β-strand	37-43	7	56
β-strand	54-60	7	12
β-strand	95-98	4	12
β-strand	100-103	4	56
β-strand	115-118	4	56
β-strand	121-124	4	56
β-strand	141-145	5	12

Chain I: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	57
α-helix	12	1
β-strand	13	1	57
β-strand	14-19	6	58
β-strand	24-29	6	58
β-strand	35-37	3	58
β-strand	42-47	6	26
α-helix	62-64	3
β-strand	70-71	2	59
β-strand	83-87	5	59
β-strand	99-103	5	59
β-strand	109-111	3	59

Chain J: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	60
β-strand	13	1	60
α-helix	18-26	9
α-helix	32-38	7
α-helix	44-51	8
β-strand	53	1	40
α-helix	57-60	4

3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1733	SACCHAROMYCES CEREVISIAE	P04050 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB2	B	protein	1224	SACCHAROMYCES CEREVISIAE	P08518 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	318	SACCHAROMYCES CEREVISIAE	P16370 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	SACCHAROMYCES CEREVISIAE	P20434 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	SACCHAROMYCES CEREVISIAE	P20435
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	SACCHAROMYCES CEREVISIAE	P20436
DNA-directed RNA polymerase II subunit RPB9	I	protein	122	SACCHAROMYCES CEREVISIAE	P27999
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	SACCHAROMYCES CEREVISIAE	P22139
DNA-directed RNA polymerase II subunit RPB11	K	protein	120	SACCHAROMYCES CEREVISIAE	P38902
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	SACCHAROMYCES CEREVISIAE	P40422
Alpha-amanitin	M	protein	8	AMANITA PHALLOIDES	P85421

Sequence of entity 1 (A), FASTA

>3CQZ_1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (chains A)
MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGS
IDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNE
LMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLK
LVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLP
VPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLE
LDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNA
DFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSP
KDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVR
FLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRR
LVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNI
RRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMT
LNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEH
TTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRA
AMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHML
KKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVP
GIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGG
LTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGA
FDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGS
NDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTS
PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS
PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR

Sequence of entity 2 (B), FASTA

>3CQZ_2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (chains B)
MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQ
DIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLR
NLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCY
LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEI
RSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH
ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVS
QVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLS
LMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETL
RTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAK
LMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEEND
LDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIA
PGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDG
LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKK
LMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAA
KLLFQELMAMNITPRLYTDRSRDF

Sequence of entity 3 (C), FASTA

>3CQZ_3 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (chains C)
MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLAD
EFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVI
VSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEY
DPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPV
DQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPY
SNASQMGNTGSGGYDNAW

Sequence of entity 4 (E), FASTA

>3CQZ_4 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 5 (F), FASTA

>3CQZ_5 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 6 (H), FASTA

>3CQZ_6 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 7 (I), FASTA

>3CQZ_7 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 (chains I)
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQ
DIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQ
FS

Sequence of entity 8 (J), FASTA

>3CQZ_8 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 9 (K), FASTA

>3CQZ_9 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 (chains K)
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAA
YKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF

Sequence of entity 10 (L), FASTA

>3CQZ_10 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Sequence of entity 11 (M), FASTA

>3CQZ_11 ALPHA-AMANITIN (chains M)
IWGIGCNP

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8

Primary citation

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin. Kaplan, C.D., Larsson, K.M., Kornberg, R.D. Mol Cell (2008) 30:547. DOI 10.1016/J.MOLCEL.2008.04.023 · PubMed

Other PDB entries of the same protein (UniProt P04050 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5VKO 1.8 Å, SPT6 tSH2-RPB1 1468-1500 pT1471, pS1493
9SV6 1.96 Å, CryoEM structure of transcribing RNA polymerase II elongation complex with ATP and Elf1
5VKL 2.2 Å, SPT6 tSH2-RPB1 1476-1500 pS1493
9W8V 2.23 Å, Structure of post-translocation state of yeast Pol II complexed with a cisplatin-induced…
9QEB 2.26 Å, CryoEM structure of transcribing RNA polymerase II elongation complex
1TWF 2.3 Å, RNA polymerase II complexed with UTP at 2.3 A resolution
9RYB 2.33 Å, CryoEM structure of transcribing RNA polymerase II elongation complex in post-catalysis…
9KD8 2.46 Å, The structure of RNA polymerase II elongation complex paused at N-2 state by actinomycin…
6NPW 2.49 Å, SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide
9K7F 2.5 Å, RNA polymerase II elongation complex apo structure.
30ES 2.54 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…
30EP 2.55 Å, Cryo-EM structure of the yeast RNA polymerase II elongation complex with 19-mer RNA in…

Browse structure collections

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