3E9L: Human Prp8, Residues 1755-2016

Crystal Structure of Human Prp8, Residues 1755-2016. Determined by X-ray diffraction at 1.95 Å resolution. Released 7 Oct 2008.

Method: X-ray diffraction
Resolution: 1.95 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,446
Mol. weight: 29.59 kDa
Released: 7 Oct 2008

Explore 3E9L in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3E9L contains 14 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	1761-1763	3	1
α-helix	1768-1772	5
β-strand	1777-1781	5	2
β-strand	1787-1792	6	3
β-strand	1798-1803	6	3
β-strand	1805-1810	6	2
β-strand	1816-1822	7	2
α-helix	1824-1827	4
α-helix	1833-1851	19
α-helix	1854-1856	3
β-strand	1860-1863	4	2
α-helix	1866-1868	3
α-helix	1869-1875	7
β-strand	1883-1885	3	2
β-strand	1886-1887	2	1
α-helix	1893-1898	6
α-helix	1900-1908	9
β-strand	1913-1918	6	2
α-helix	1923-1925	3
α-helix	1929-1945	17
α-helix	1947-1953	7
α-helix	1973-1995	23
α-helix	1999-2001	3
α-helix	2004-2012	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Pre-mRNA-processing-splicing factor 8	A	protein	257	Homo sapiens	Q6P2Q9 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3E9L_1 Pre-mRNA-processing-splicing factor 8 (chains A)
EPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFL
KIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDF
PNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILI
LRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVEVQLKDLILADYGKKNNVNV
ASLTQSEIRDIILGMEI

Primary citation

Structure and function of an RNase H domain at the heart of the spliceosome. Pena, V., Rozov, A., Fabrizio, P. et al. EMBO J (2008) 27:2929-2940. DOI 10.1038/emboj.2008.209 · PubMed

Other PDB entries of the same protein (UniProt Q6P2Q9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4JK8 1.15 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion
4JKB 1.3 Å, Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion
4JKA 1.32 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion
4JK7 1.4 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion
4JK9 1.5 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion
4JKC 1.5 Å, Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
4JKD 1.55 Å, Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion
4JKE 1.65 Å, Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion
4JKG 1.8 Å, Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain…
4JKH 1.8 Å, Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion
3ENB 1.85 Å, Crystal Structure of PRP8 core domain IV
3LRU 1.85 Å, hPRP8 Non-Native Subdomain

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