3FEV: PDB entry 3FEV

Name: PDB 3FEV: Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1.
Published: 2009-12-22
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: toxin

Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1. Determined by X-ray diffraction at 1.3 Å resolution. Released 22 Dec 2009.

Method: X-ray diffraction
Resolution: 1.3 Å
Organism: Dendroaspis angusticeps
Chains: 3
Atoms: 2,154
Mol. weight: 22.32 kDa
Released: 22 Dec 2009

Explore 3FEV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3FEV contains 6 α-helices and 15 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	2-8	7	1
β-strand	11-16	6	1
α-helix	17-18	2
β-strand	23-32	10	2
β-strand	35-43	9	2
α-helix	47-50	4
β-strand	54-58	5	2

Chain B: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	2
β-strand	12-16	5	2
α-helix	17-18	2
β-strand	23-32	10	3
β-strand	35-43	9	3
α-helix	46-49	4
β-strand	54-58	5	3

Chain C: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	2-8	7	4
β-strand	11-16	6	4
α-helix	17-18	2
β-strand	23-31	9	5
β-strand	35-43	9	5
α-helix	47-49	3
β-strand	54-58	5	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1	A, B, C	protein	65	Dendroaspis angusticeps	P81030 (AlphaFold model), Q8QGR0 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>3FEV_1 Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1 (chains A, B, C)
LTCVTSKSIFGITTENCPDGQNLCFKRWQYISPRMYDFTRGCAATCPKAEYRDVINCCGT
DKCNK

Primary citation

Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Fruchart-Gaillard, C., Mourier, G., Blanchet, G. et al. PLoS One (2012) 7:e39166-e39166. DOI 10.1371/journal.pone.0039166 · PubMed

Other PDB entries of the same protein (UniProt P81030 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3NEQ 1.25 Å, Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1
4DO8 1.8 Å, Crystal structure of the muscarinic toxin MT1

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