Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes. Determined by X-ray diffraction at 1.65 Å resolution. Released 3 Mar 2009.
Explore 3FQN in 3D Show helices and sheets RCSB PDB PDBe
3FQN contains 14 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-12 | 10 | 1 |
| α-helix | 19-20 | 2 | |
| β-strand | 21-28 | 8 | 1 |
| β-strand | 31-37 | 7 | 1 |
| β-strand | 46-47 | 2 | 1 |
| α-helix | 50-52 | 3 | |
| α-helix | 57-84 | 28 | |
| β-strand | 94-103 | 10 | 1 |
| β-strand | 109-118 | 10 | 1 |
| β-strand | 121-126 | 6 | 1 |
| β-strand | 133-135 | 3 | 1 |
| α-helix | 138-149 | 12 | |
| α-helix | 152-158 | 7 | |
| α-helix | 159-163 | 5 | |
| α-helix | 164-174 | 11 | |
| α-helix | 176-179 | 4 | |
| β-strand | 183 | 1 | 2 |
| α-helix | 184-185 | 2 | |
| β-strand | 186-193 | 8 | 3 |
| β-strand | 198-208 | 11 | 3 |
| β-strand | 209 | 1 | 2 |
| β-strand | 214-219 | 6 | 4 |
| β-strand | 222-224 | 3 | 4 |
| β-strand | 228-230 | 3 | 3 |
| α-helix | 231-233 | 3 | |
| β-strand | 234-235 | 2 | 3 |
| β-strand | 241-250 | 10 | 3 |
| α-helix | 254-256 | 3 | |
| β-strand | 257-262 | 6 | 4 |
| β-strand | 270-273 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 5 |
| α-helix | 3-4 | 2 | |
| β-strand | 5-10 | 6 | 6 |
| β-strand | 20-29 | 10 | 6 |
| β-strand | 30 | 1 | 5 |
| β-strand | 35-40 | 6 | 7 |
| β-strand | 43-44 | 2 | 7 |
| α-helix | 45 | 1 | |
| β-strand | 49-50 | 2 | 6 |
| α-helix | 51-53 | 3 | |
| β-strand | 54-55 | 2 | 6 |
| β-strand | 61-69 | 9 | 6 |
| β-strand | 77-82 | 6 | 7 |
| β-strand | 90-93 | 4 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| HLA class I histocompatibility antigen, A-2 alpha chain | A | protein | 275 | Homo sapiens | P04439 (AlphaFold model) |
| Beta-2-microglobulin | B | protein | 98 | Homo sapiens | P61769 (AlphaFold model) |
| peptide 30-39 from beta-Catenin: YLDSGIHSGA | C | protein | 10 | Homo sapiens | P35222 (AlphaFold model) |
>3FQN_1 HLA class I histocompatibility antigen, A-2 alpha chain (chains A) GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE
>3FQN_2 Beta-2-microglobulin (chains B) QRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWS FYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
>3FQN_3 peptide 30-39 from beta-Catenin: YLDSGIHSGA (chains C) YLDSGIHSGA
Water and common crystallization additives (GOL) are not listed.
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes. Petersen, J., Wurzbacher, S.J., Williamson, N.A. et al. Proc Natl Acad Sci U S A (2009) 106:2776-2781. DOI 10.1073/pnas.0812901106 · PubMed
Other PDB entries of the same protein (UniProt P04439 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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