3IQS: Anti-viral APOBEC3G catalytic domain

Crystal structure of the anti-viral APOBEC3G catalytic domain. Determined by X-ray diffraction at 2.3 Å resolution. Released 10 Nov 2009.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,552
Mol. weight: 22.15 kDa
Ligands: ZN
Released: 10 Nov 2009

Explore 3IQS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3IQS contains 10 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	199-206	8
β-strand	219-226	8	1
β-strand	235-243	9	1
β-strand	245	1	2
β-strand	256	1	2
α-helix	258-265	8
α-helix	266-269	4
β-strand	277-283	7	1
α-helix	286-288	3
α-helix	289-302	14
β-strand	305-311	7	1
α-helix	321-330	10
β-strand	334-337	4	1
α-helix	340-350	11
α-helix	356-358	3
α-helix	360-361	2
α-helix	364-379	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA dC->dU-editing enzyme APOBEC-3G	A	protein	189	Homo sapiens	Q9HC16 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3IQS_1 DNA dC->dU-editing enzyme APOBEC-3G (chains A)
GPLGSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHG
FLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFT
ARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDL
SGRLRAILQ

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Holden, L.G., Prochnow, C., Chang, Y.P. et al. Nature (2008) 456:121-124. DOI 10.1038/nature07357 · PubMed

Other PDB entries of the same protein (UniProt Q9HC16 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3V4K 1.38 Å, First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase…
7UXD 1.5 Å, Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy…
4ROW 1.7 Å, The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode…
4ROV 1.8 Å, The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode…
6BUX 1.86 Å, Crystal structure of APOBEC3G catalytic domain complex with substrate ssDNA
5ZVB 2.0 Å, APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dT9)
3V4J 2.04 Å, First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase…
3IR2 2.25 Å, Crystal structure of the APOBEC3G catalytic domain
3E1U 2.3 Å, The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain
5ZVA 2.3 Å, APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9)
8J62 2.5 Å, Cryo-EM structure of APOBEC3G-Vif complex
8CX0 2.7 Å, Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex

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